Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Balsalazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.51 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.51 |
| ▸ | SIRT5 | Q9NXA8 | 5/20 | 1.00 |
| ▸ | NME4 | O00746 | 3/20 | 1.00 |
| ▸ | GCDH | Q92947 | 3/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | ADORA2A | P29274 | 1/20 | 1.00 |
| ▸ | AVPR2 | P30518 | 1/20 | 1.00 |
| ▸ | AGTR1 | P30556 | 1/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 1/20 | 1.00 |
| ▸ | AVPR1A | P37288 | 1/20 | 1.00 |
| ▸ | HTR3A | P46098 | 1/20 | 1.00 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | BLVRB | P30043 | 2/20 | 0.59 |
| ▸ | PDE4A | P27815 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Balsalazide SCHEMBL138311 | 1.00 | SIRT5 (1.00) | SIRT5NME4GCDHTDP1HRH3 | |
| Balsalazide SCHEMBL29377041 | 1.00 | SIRT5 (1.00) | SIRT5NME4GCDHTDP1HRH3 | |
| Balsalazide SCHEMBL118300 | 1.00 | SIRT5 (1.00) | SIRT5NME4GCDHTDP1HRH3 | |
| Balsalazide SCHEMBL7908058 | 0.99 | SIRT5 (0.97) | SIRT5NME4GCDHTDP1HRH3 | |
| Balsalazide SCHEMBL28818120 | 0.99 | SIRT5 (0.97) | SIRT5NME4GCDHTDP1HRH3 | |
| Balsalazide SCHEMBL134019 | 0.99 | SIRT5 (0.97) | SIRT5NME4GCDHTDP1HRH3 | |
| Balsalazide SCHEMBL5598491 | 0.99 | SIRT5 (0.97) | SIRT5NME4GCDHTDP1HRH3 | |
| Balsalazide SCHEMBL133200 | 0.97 | SIRT5 (0.95) | SIRT5NME4GCDHTDP1HRH3 | |
| Balsalazide SCHEMBL20184744 | 0.93 | SIRT5 (0.87) | SIRT5NME4GCDHTDP1HRH3 | |
| Balsalazide SCHEMBL17392780 | 0.93 | SIRT5 (0.87) | SIRT5NME4GCDHTDP1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694298-B1 | METHOD FOR SELECTING CATIONIC OR ANIONIC LIPOSOMES FOR TREATMENT OF A MUCOSA MEMBRANE, AND KIT COMPRISING THE SAME | YISSUM RES DEV CO (IL) | 2010-06-09 | — | — | EP | claimed |
| US-20070212403-A1 | Method for Selecting Cationic or Anionic Liposomes for Treatment of a Mucosa Membrane, and Kit Comprising the Same | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2007-09-13 | — | — | US | claimed |
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-106459182-A | Tandem FAB immunoglobulins and uses thereof | 岸迈生物科技有限公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-103025758-B | IL-1 binding proteins | ABBVIE 公司 | 2017-01-18 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |
| CN-105793255-A | Heterocyclic compounds and their use | 无限药品股份有限公司 | 2016-07-20 | — | — | CN | disclosed |
| EP-1585530-A4 | BIOADHESIVE PHARMACEUTICAL COMPOSITIONS | BARBEAU DONALD L (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-1585530-A2 | BIOADHESIVE PHARMACEUTICAL COMPOSITIONS | Barbeau, Donald L. (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004064754-A2 | BIOADHESIVE PHARMACEUTICAL COMPOSITIONS | BARBEAU DONALD L (US) | 2004-08-05 | — | — | WO | disclosed |