Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Balsalazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 5/20 | 0.97 |
| ▸ | NME4 | O00746 | 3/20 | 0.97 |
| ▸ | GCDH | Q92947 | 3/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.97 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.97 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.97 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.97 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.97 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.97 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.97 |
| ▸ | HTR3A | P46098 | 1/20 | 0.97 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.97 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | BLVRB | P30043 | 2/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Balsalazide SCHEMBL134019 | 1.00 | SIRT5 (0.97) | SIRT5NME4GCDHTDP1HRH3 | |
| Balsalazide SCHEMBL28818120 | 1.00 | SIRT5 (0.97) | SIRT5NME4GCDHTDP1HRH3 | |
| Balsalazide SCHEMBL133200 | 0.99 | SIRT5 (0.95) | SIRT5NME4GCDHTDP1HRH3 | |
| Balsalazide SCHEMBL29377041 | 0.99 | SIRT5 (1.00) | SIRT5NME4GCDHTDP1HRH3 | |
| Balsalazide SCHEMBL3267109 | 0.99 | SIRT5 (1.00) | SIRT5NME4GCDHTDP1HRH3 | |
| Balsalazide SCHEMBL118300 | 0.99 | SIRT5 (1.00) | SIRT5NME4GCDHTDP1HRH3 | |
| Balsalazide SCHEMBL138311 | 0.99 | SIRT5 (1.00) | SIRT5NME4GCDHTDP1HRH3 | |
| Balsalazide SCHEMBL5598491 | 0.97 | SIRT5 (0.97) | SIRT5NME4GCDHTDP1HRH3 | |
| Balsalazide SCHEMBL20184744 | 0.92 | SIRT5 (0.87) | SIRT5NME4GCDHTDP1HRH3 | |
| Balsalazide SCHEMBL17392780 | 0.92 | SIRT5 (0.87) | SIRT5NME4GCDHTDP1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113970607-B | Detection method of related substances in balsalazide sodium capsules | 马应龙药业集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-116687940-A | Application of balsalazide sodium hydrate in treating colorectal cancer and treatment target | 太仓市第一人民医院 | 2023-09-05 | — | — | CN | disclosed |
| CN-116271060-A | Pharmaceutical composition, preparation method and application thereof | 优畅达(武汉)医疗科技有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-115151641-A | Human chromosome 9 open reading frame 72 (C9 ORF 72) iRNA agent compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2022-10-04 | — | — | CN | disclosed |
| CN-112020556-A | 17 beta hydroxysteroid dehydrogenase type 13 (HSD17B13) iRNA compositions and methods of use thereof | 瑞泽恩制药公司 | 2020-12-01 | — | — | CN | disclosed |
| US-6197341-B1 | DRUGS AND BINDERS | Salix Pharmaceuticals, Ltd | 2001-03-06 | — | — | US | disclosed |
| EP-1003524-A1 | NEW FORMULATION | AstraZeneca AB (SE) | 2000-05-31 | — | — | EP | disclosed |
| WO-1998041212-A1 | NEW FORMULATION | ASTRA AKTIEBOLAG (PUBL) (SE) | 1998-09-24 | — | — | WO | disclosed |