Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.94 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL29373911 | 0.97 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL28819407 | 0.97 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL18393648 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL3593172 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL3596014 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL674137 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL20994738 | 0.94 | — | — | |
| Malic Acid SCHEMBL21815634 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL21815132 | 0.94 | CA4 (1.00) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL162118 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 504 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4724077-A1 | COMBINATION OF BACTERIAL STRAINS TO INHIBIT PATHOGENS IN ANIMALS | Phibro Animal Health Corporation (US) | 2026-04-15 | — | — | EP | claimed |
| US-20250057750-A1 | COSMETIC COMPOSITION | GIVAUDAN SA (CH) | 2025-02-20 | — | — | US | claimed |
| WO-2025029611-A1 | THERAPIES FOR DISEASES OF COPPER METABOLISM | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2025-02-06 | — | — | WO | claimed |
| WO-2024254006-A1 | COMBINATION OF BACTERIAL STRAINS TO INHIBIT PATHOGENS IN ANIMALS | PHIBRO ANIMAL HEALTH CORPORATION (US) | 2024-12-12 | — | — | WO | claimed |
| EP-4469018-A1 | COSMETIC COMPOSITION | Givaudan SA (CH) | 2024-12-04 | — | — | EP | claimed |
| CN-118744978-A | High-magnification hard carbon negative electrode material and preparation method thereof | 泰安市法拉第能源科技有限公司 | 2024-10-08 | — | — | CN | claimed |
| US-12091371-B2 | Organic fertilizer for controlling pollution or accumulation of heavy metal cadmium in rice and preparation method and application method thereof | CHINA NATIONAL RICE RESEARCH INSTITUTE (CN) | 2024-09-17 | — | — | US | claimed |
| CN-118591366-A | Cosmetic composition | 奇华顿股份有限公司 | 2024-09-03 | — | — | CN | claimed |
| CN-114134505-B | Alkaline microetching roughening solution and circuit board lead roughening method | 上海贝尼塔实业有限公司 | 2024-07-05 | — | — | CN | claimed |
| CN-114914011-B | Repairing type silver-coated copper powder and preparation method thereof, electronic paste and preparation method thereof | 苏州思尔维纳米科技有限公司 | 2024-03-08 | — | — | CN | claimed |
| US-5972402-A | Process for eliminating smell defects and/or off-flavors in fermented or non-fermented fruit juices, in particular wine, fruit wine or fruit distillate products | Erbslohr-Getranke-Technologie GmbH & Co. KG (DE) | 1999-10-26 | — | — | US | claimed |
| US-5211940-A | Copper carboxylic acids with storage stability | LION CORPORATION (JP) | 1993-05-18 | — | — | US | claimed |
| US-5019599-A | Containing A Diels-Alder Reaction Product And Optionally A Copper Compound | NIPPON ZEON CO., LTD. (JP) | 1991-05-28 | — | — | US | claimed |
| US-4959207-A | ANHYDRIDE CONTAINING POLYMER OR MONOMER, COPPER COMPOUND | NIPPON ZEON CO., LTD. (JP) | 1990-09-25 | — | — | US | claimed |
| US-4906462-A | Deodorant composition and deodorant composite material | NIPPON ZEON CO., LTD. (JP) | 1990-03-06 | — | — | US | claimed |
| US-4824661-A | COPPER SALT, 2,4,4*-TRICHLORO-2*-HYDROXYDIPHENYL ETHER | BLENDAX-WERKE R. SCHNEIDER GMBH & CO. (DE) | 1989-04-25 | — | — | US | claimed |
| EP-0038867-B1 | TOOTHPASTE | Blendax-Werke R. Schneider GmbH & Co. (DE) | 1983-09-28 | — | — | EP | claimed |
| EP-0038868-B1 | TOOTHPASTE | Blendax-Werke R. Schneider GmbH & Co. (DE) | 1983-09-28 | — | — | EP | claimed |
| US-4339429-A | Toothpaste active against plaque comprising a copper compound and a plastic polishing agent | BLENDAX-WERKE R. SCHNEIDER GMBH & CO. (DE) | 1982-07-13 | — | — | US | claimed |
| US-4332791-A | NONDISCOLORING | BLENDAX-WERKE R. SCHNEIDER GMBH & CO. (DE) | 1982-06-01 | — | — | US | claimed |