Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.94 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL5013575 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL18981017 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL20994738 | 0.94 | — | — | |
| Malic Acid SCHEMBL674137 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL2784551 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL118155 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL21815132 | 0.94 | CA4 (1.00) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL21815634 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL1093517 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL121544 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 198 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117339018-A | Method for rapidly surface loading strontium ions before implant operation | 山东大学 | 2024-01-05 | — | — | CN | claimed |
| CN-109499618-B | Catalyst for preparing benzoylformic acid and ester compounds thereof, and preparation method and application thereof | 陕西延长石油（集团）有限责任公司 | 2021-06-15 | — | — | CN | claimed |
| CN-109499618-A | A kind of catalyst and the preparation method and application thereof being used to prepare benzoyl formic acid and its ester type compound | 陕西延长石油（集团）有限责任公司 | 2019-03-22 | — | — | CN | claimed |
| WO-2014044756-A1 | STRONTIUM AS ANTI MICROBIAL COMPOUND | Mokwalo SA (LU) | 2014-03-27 | — | — | WO | claimed |
| US-8642679-B2 | Dental cement composition | GC CORPORATION (JP) | 2014-02-04 | — | — | US | claimed |
| EP-2097137-B1 | COMPOSITIONS COMPRISING STRONTIUM AND USES THEREOF IN THE TREATMENT OR PREVENTION OF GINGIVITIS, PERIODONTITIS, PERIODONTITIS AS A MANIFESTATION OF SYSTEMIC DISEASES, AND NECROTIZING PERIODONTAL DISEASES. | MOKWALO SPF S A (LU) | 2012-09-19 | — | — | EP | claimed |
| EP-2416756-A2 | STABLE PHARMACEUTICAL COMPOSITIONS WITH HIGH BIOAVAILIBILITY | Bilgic, Mahmut (TR) | 2012-02-15 | — | — | EP | claimed |
| US-20110130370-A1 | Pharmaceutical composition comprising a strontium salt, vitamin D and A cyclodextrin | LES LABORATORIES SERVIER (FR) | 2011-06-02 | — | — | US | claimed |
| US-20100272802-A1 | COMPOSITIONS COMPRISING STRONTIUM AND USES THEREOF IN THE TREATMENT OR PREVENTION OF GINGIVITIS, PERIODONTITIS, PERIODONTITIS AS A MANIFESTATION OF SYSTEMIC DISEASES, AND NECROTIZING PERIODONTAL DISEASES | MOKWALO SPF S.A., LUXEMBOURG (LU) | 2010-10-28 | — | — | US | claimed |
| WO-2010117346-A2 | STABLE PHARMACEUTICAL COMPOSITIONS WITH HIGH BIOAVAILIBILITY | BILGIC MAHMUT (TR) | 2010-10-14 | — | — | WO | claimed |
| WO-2007149815-A1 | STRONTIUM COMPOSITIONS AND METHODS OF TREATING ARTHRITIC AND OR OSTEOPORITIC CONDITIONS | THERAGENEX, LLC (US) | 2007-12-27 | — | — | WO | claimed |
| US-20070292535-A1 | Strontium compositions and methods of treating arthritic and or osteoporitic conditions | TRX PHARMACEUTICALS, LLC | 2007-12-20 | — | — | US | claimed |
| US-20070292529-A1 | Strontium compositions and methods of treating osteoporotic conditions | TRX PHARMACEUTICALS, LLC | 2007-12-20 | — | — | US | claimed |
| CN-101018586-A | Composition containing strontium and vitamin D and application thereof | STRONTIN APS (DK) | 2007-08-15 | — | — | CN | claimed |
| EP-1768748-A2 | COMPOSITIONS COMPRISING STRONTIUM AND VITAMIN D AND USES THEREOF | Strontin APS (DK) | 2007-04-04 | — | — | EP | claimed |
| CN-1887294-A | Orally taken liquid medicine composition containing strontium | HENAN FUREN PHARMACEUTICAL IND (CN) | 2007-01-03 | — | — | CN | claimed |
| CN-1824735-A | Preparation of curcas biological diesel oil by solid phase catalytic method | UNIV GUIZHOU (CN) | 2006-08-30 | — | — | CN | claimed |
| WO-2006000224-A2 | COMPOSITIONS COMPRISING STRONTIUM AND VITAMIN D AND USES THEREOF | STRONTIN APS (DK) | 2006-01-05 | — | — | WO | claimed |
| CN-1136856-C | Use of strontium salts for production of pharmaceutical compositions intended for treatment of arthrosis | ɪά��ʵ���� | 2004-02-04 | — | — | CN | claimed |
| US-5051394-A | Precipitation and roasting | AGENCY OF INDUSTRIAL SCIENCE & TECHNOLOGY (JP) | 1991-09-24 | — | — | US | claimed |