Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.94 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL18393648 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL5013575 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL21815634 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL162118 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL118155 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL1093517 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL20994738 | 0.94 | — | — | |
| Malic Acid SCHEMBL21815132 | 0.94 | CA4 (1.00) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL3596014 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL2784551 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113260-A1 | Ruthenium compositions and methods of making the same | SYMYX TECHNOLOGIES, INC. (US) | 2010-05-06 | — | — | US | disclosed |
| US-20090286678-A1 | High Surface Area Metal And Metal Oxide Materials and Methods of Making the Same | SYMYX TECHNOLOGIES, INC. (US) | 2009-11-19 | — | — | US | disclosed |
| US-20090270251-A1 | Cobalt compositions and methods of making the same | SYMYX TECHNOLOGIES, INC. (US) | 2009-10-29 | — | — | US | disclosed |
| US-20090215613-A1 | Yttrium Compositions And Methods of Making the Same | SYMYX TECHNOLOGIES, INC. (US) | 2009-08-27 | — | — | US | disclosed |
| US-20090187036-A1 | Nickel Compositions And Methods of Making the Same | SYMYX TECHNOLOGIES, INC. (US) | 2009-07-23 | — | — | US | disclosed |
| US-20090182160-A1 | Vanadium Compositions And Methods of Making the Same | SYMYX TECHNOLOGIES, INC. (US) | 2009-07-16 | — | — | US | disclosed |
| US-20090029852-A1 | Molybdenum Compositions And Methods of Making the Same | FREESLATE, INC. | 2009-01-29 | — | — | US | disclosed |
| US-20090011930-A1 | Cerium Compositions and Methods of Making the Same | SYMYX TECHNOLOGIES, INC. (US) | 2009-01-08 | — | — | US | disclosed |
| EP-1879833-A2 | HIGH SURFACE AREA METAL AND METAL OXIDE MATERIALS AND METHODS OF MAKING SAME | Symyx Technologies, Inc. (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006119311-A2 | HIGH SURFACE AREA METAL AND METAL OXIDE MATERIALS AND METHODS OF MAKING SAME | SYMYX TECHNOLOGIES, INC. (US) | 2006-11-09 | — | — | WO | disclosed |