Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 7/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.45 |
| ▸ | GABRD | O14764 | 1/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.45 |
| ▸ | ALB | P02768 | 1/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | GABRE | P78334 | 1/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11838255 | 0.88 | GABRA1 (0.46) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL11833332 | 0.86 | GABRA1 (0.38) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL11823482 | 0.86 | GABRA1 (0.45) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL11826517 | 0.85 | CHRM1 (0.47) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL11826451 | 0.85 | CYP1A2 (0.33) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL11822656 | 0.84 | CHRM1 (0.47) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL11827831 | 0.84 | GABRA1 (0.48) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL5178956 | 0.84 | OPRK1 (0.49) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL11084467 | 0.83 | OPRK1 (0.45) | OPRK1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL11829527 | 0.83 | CHRM1 (0.47) | OPRK1GABRA1GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3933794-A | CENTRAL NERVOUS SYSTEM DEPRESSANTS | THE UPJOHN COMPANY (US) | 1976-01-20 | — | — | US | disclosed |