Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 9/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11842920 | 0.86 | GABRA1 (0.53) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11826561 | 0.86 | PTAFR (0.52) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11823721 | 0.85 | CHRM1 (0.45) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL10693964 | 0.84 | GABRA1 (0.54) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11809246 | 0.84 | OPRK1 (0.69) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11832211 | 0.84 | GABRA5 (0.51) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11826946 | 0.84 | GABRA1 (0.69) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11829806 | 0.83 | CHRM1 (0.30) | CHRM1 | |
| SCHEMBL7328513 | 0.83 | GABRA1 (0.71) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11836500 | 0.82 | GABRA1 (0.49) | GABRA1GABRA5GABRA2GABRB2GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3933794-A | CENTRAL NERVOUS SYSTEM DEPRESSANTS | THE UPJOHN COMPANY (US) | 1976-01-20 | — | — | US | disclosed |