SCHEMBL11838457

SCHEMBL11838457

CNC(=O)Nc1ccc(Oc2ccc(N)cc2Cl)cc1Cl

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 9/20 0.51
PNLIP P16233 1/20 0.46
MEN1 O00255 1/20 0.44
MAPT P10636 1/20 0.44
KMT2A Q03164 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
HSD17B10 Q99714 1/20 0.43
HTR2A P28223 3/20 0.42
SLC6A4 P31645 2/20 0.42
PYGL P06737 1/20 0.41
PDE7A Q13946 1/20 0.41
GCK P35557 1/20 0.41
GFER P55789 1/20 0.40
KCNH2 Q12809 1/20 0.40
RET P07949 3/20 0.40
KIT P10721 3/20 0.40
PDGFRA P16234 3/20 0.40
FLT1 P17948 3/20 0.40
FLT4 P35916 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11828173 0.82 MEN1 (0.61) MEN1MAPTKMT2ASMN1; SMN2NPSR1
SCHEMBL11839317 0.79 STK39 (0.58) KDRMEN1MAPTKMT2ASMN1; SMN2
SCHEMBL4686393 0.76 PNLIP (0.45) KDRPNLIPMEN1MAPTKMT2A
SCHEMBL9054295 0.76 CYP1A2 (0.47) MEN1MAPTKMT2ANPSR1HTR2A
SCHEMBL11460671 0.74 HTR2A (0.63) PNLIPHTR2ASLC6A4PDE7AKCNH2
SCHEMBL11834191 0.73 KDR (0.45) KDRMEN1MAPTKMT2ANPSR1
SCHEMBL8320103 0.73 FFAR1 (0.51) KDRMEN1MAPTKMT2AHTR2A
SCHEMBL11841770 0.73 KDR (0.57) KDRMEN1MAPTKMT2ASMN1; SMN2
SCHEMBL7184491 0.73 PDE7A (0.53) PNLIPMEN1MAPTKMT2ASMN1; SMN2
SCHEMBL617620 0.72 KDR (0.50) KDRMEN1KMT2AHTR2ARET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3933814-A ANTIPROTOZOA, ANTICOCCIDIOSIS BAYER AKTIENGESELLSCHAFT (DT) 1976-01-20 US disclosed