SCHEMBL11839655

SCHEMBL11839655

CSc1nc(=O)n(-c2ccc(Cl)cc2)c(=O)n1C

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.45
GSK3A P49840 1/20 0.43
GSK3B P49841 1/20 0.43
SMN1; SMN2 Q16637 3/20 0.42
GAA P10253 2/20 0.42
NPC1 O15118 1/20 0.42
LMNA P02545 1/20 0.42
MAPT P10636 1/20 0.42
HTT P42858 1/20 0.42
RAB9A P51151 1/20 0.42
POLB P06746 3/20 0.41
TLR8 Q9NR97 2/20 0.41
ATM Q13315 1/20 0.39
APOBEC3G Q9HC16 1/20 0.39
KMT2A Q03164 2/20 0.38
GSR P00390 1/20 0.38
MAT2A P31153 2/20 0.36
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
MEN1 O00255 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11838907 0.86 NPC1 (0.35) ALDH1A1SMN1; SMN2NPC1LMNARAB9A
SCHEMBL11844568 0.84 ALDH1A1 (0.47) ALDH1A1GSK3AGSK3BSMN1; SMN2NPC1
SCHEMBL11840933 0.84 RAB9A (0.46) ALDH1A1SMN1; SMN2NPC1LMNAMAPT
SCHEMBL9792477 0.80 POLB (0.47) ALDH1A1GSK3AGSK3BSMN1; SMN2GAA
SCHEMBL11523147 0.76 GSK3A (0.43) ALDH1A1GSK3AGSK3BSMN1; SMN2GAA
SCHEMBL11849299 0.76 GSK3A (0.43) ALDH1A1GSK3AGSK3BSMN1; SMN2GAA
SCHEMBL4756566 0.70 SMN1; SMN2 (0.44) ALDH1A1SMN1; SMN2NPC1LMNAMAPT
SCHEMBL11392730 0.70 SMN1; SMN2 (0.48) SMN1; SMN2GAANPC1LMNAMAPT
SCHEMBL7085417 0.69 POLB (0.41) ALDH1A1SMN1; SMN2MAPTRAB9APOLB
SCHEMBL11824631 0.69 SMN1; SMN2 (0.47) SMN1; SMN2GAANPC1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3983116-A Herbicidal triazines E. I. DU PONT DE NEMOURS AND COMPANY (US) 1976-09-28 US disclosed