Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755234 | 0.78 | POLB (0.45) | SMN1; SMN2POLBLMNARAB9ANPC1 | |
| SCHEMBL4756615 | 0.78 | KMT2A (0.41) | KMT2ANPSR1MEN1MAPTHTR6 | |
| SCHEMBL1101909 | 0.75 | LMNA (0.72) | SMN1; SMN2LMNAALDH1A1KMT2ANPSR1 | |
| SCHEMBL7085417 | 0.75 | POLB (0.41) | SMN1; SMN2POLBRAB9AALDH1A1TLR8 | |
| SCHEMBL5437956 | 0.72 | ATM (0.42) | SMN1; SMN2POLBLMNAALDH1A1GRM1 | |
| SCHEMBL13985230 | 0.71 | DRD1 (0.39) | SMN1; SMN2POLBRAB9ANPC1ALDH1A1 | |
| SCHEMBL4753340 | 0.71 | DRD1 (0.39) | SMN1; SMN2POLBRAB9ANPC1ALDH1A1 | |
| SCHEMBL11839655 | 0.70 | ALDH1A1 (0.45) | SMN1; SMN2POLBLMNARAB9ANPC1 | |
| SCHEMBL7969946 | 0.70 | ALDH1A1 (0.53) | SMN1; SMN2POLBLMNAALDH1A1KMT2A | |
| SCHEMBL5429549 | 0.69 | XDH (0.46) | SMN1; SMN2POLBLMNARAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |