Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27349799 | 0.91 | USP30 (0.48) | MAPTUSP30MEN1KMT2AALDH1A1 | |
| SCHEMBL11836392 | 0.83 | PKM (0.45) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL25388905 | 0.81 | MAPT (0.47) | MAPTUSP30MEN1KMT2AALDH1A1 | |
| SCHEMBL31288366 | 0.81 | MAPT (0.47) | MAPTUSP30MEN1KMT2AALDH1A1 | |
| SCHEMBL31282954 | 0.81 | MAPT (0.47) | MAPTUSP30MEN1KMT2AALDH1A1 | |
| SCHEMBL31282832 | 0.81 | MAPT (0.47) | MAPTUSP30MEN1KMT2AALDH1A1 | |
| SCHEMBL31282640 | 0.81 | MAPT (0.47) | MAPTUSP30MEN1KMT2AALDH1A1 | |
| SCHEMBL25388421 | 0.80 | MAPT (0.50) | MAPTMEN1KMT2ADRD2DRD4 | |
| SCHEMBL25389728 | 0.80 | MAPT (0.50) | MAPTMEN1KMT2ADRD2DRD4 | |
| SCHEMBL25389700 | 0.80 | MAPT (0.50) | MAPTMEN1KMT2ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3989707-A | NEUROLEPTIC AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1976-11-02 | — | — | US | disclosed |