SCHEMBL118609

SCHEMBL118609

O=CC(Br)c1ccc(Cl)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.42
TSHR P16473 3/20 0.41
MAPK1 P28482 2/20 0.41
HIF1A Q16665 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
LMNA P02545 2/20 0.39
TP53 P04637 1/20 0.39
HPGD P15428 1/20 0.39
ADRB2 P07550 1/20 0.39
CYP2A6 P11509 1/20 0.38
BRD4 O60885 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38
HDAC5 Q9UQL6 1/20 0.38
FFAR2 O15552 1/20 0.37
CYP19A1 P11511 3/20 0.37
IDO1 P14902 1/20 0.37
TDO2 P48775 1/20 0.37
ALOX15 P16050 1/20 0.36
APEX1 P27695 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1505157 0.81 TYR (0.54) MAPK1HIF1ALMNAIDO1CYP2D6
SCHEMBL579790 0.80 ACP3 (0.31) TYR
SCHEMBL1440680 0.80 ACP3 (0.31) TYR
SCHEMBL5319312 0.79 CNR1 (0.35) TP53MEN1KMT2A
SCHEMBL22590138 0.78 CYP2A6 (0.40) MAPK1CYP2A6ALOX15MEN1CYP2C19
SCHEMBL321965 0.78 CYP2A6 (0.40) MAPK1CYP2A6ALOX15MEN1CYP2C19
SCHEMBL9874404 0.78 TSHR (0.42) HSD17B10TSHRMAPK1HIF1ATDP1
SCHEMBL21724409 0.76 TSHR (0.38) TSHRTP53IDO1TDO2
SCHEMBL21597319 0.76 CYP2A6 (0.42) TDP1LMNAHPGDCYP2A6CYP19A1
SCHEMBL21834675 0.76 ESR1 (0.44) HSD17B10TSHRHIF1ATDP1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4274569-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER Anima Biotech Inc. (US) 2023-11-15 EP disclosed
EP-4247811-A1 BICYCLO[1.1.1]PENTANE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION F. Hoffmann-La Roche AG (CH) 2023-09-27 EP disclosed
WO-2022150316-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2022-07-14 WO disclosed
WO-2022106375-A1 BICYCLO[1.1.1]PENTANE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION F. HOFFMANN-LA ROCHE AG (CH) 2022-05-27 WO disclosed
EP-3759094-A1 PIPERIDINYL-3-(ARYLOXY)PROPANAMIDES AND PROPANOATES Takeda Pharmaceutical Company Limited (JP) 2021-01-06 EP disclosed
EP-3638676-A1 SUBSTITUTED BRIDGED DIAZEPANE DERIVATIVES AND USE THEREOF AS TASK-1 AND TASK-3 INHIBITORS Bayer Pharma Aktiengesellschaft (DE) 2020-04-22 EP disclosed
EP-3638675-A1 DIAZABICYCLIC SUBSTITUTED IMIDAZOPYRIMIDINES AND THEIR USE FOR THE TREATMENT OF BREATHING DISORDERS Bayer AG (DE) 2020-04-22 EP disclosed
EP-3619209-A1 SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS NADPH OXIDASE INHIBITORS Glenmark Pharmaceuticals S.A. (CH) 2020-03-11 EP disclosed
EP-3503916-A1 INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE Bristol-Myers Squibb Company (US) 2019-07-03 EP disclosed
WO-2019104011-A1 CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE BIOMARIN PHARMACEUTICAL INC. (US) 2019-05-31 WO disclosed
EP-0891978-B1 5H-Thiazolo (3,2-a) pyrimidine derivatives HOFFMANN LA ROCHE (CH) 2002-03-20 EP disclosed
WO-2001087845-A2 N-CONTAINING HETEROCYCLIC COMPOUNDS AND THEIR USE AS 5-HT ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-11-22 WO disclosed
WO-2001060781-A2 DIPHENYL COMPOUNDS, FORMULATIONS AND USES THEREOF UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) 2001-08-23 WO disclosed
WO-2001000612-A2 RESPIRATORY SYNCYTIAL VIRUS REPLICATION INHIBITORS JANSSEN PHARMACEUTICA N.V. (BE) 2001-01-04 WO disclosed
US-5958931-A NERVOUS SYSTEM DISORDERS HOFFMANN-LA ROCHE INC. (US) 1999-09-28 US disclosed
CN-1206010-A 5H-thiazole [3,2-a] pyrimidine derivatives HOFFMANN LA ROCHE (CH) 1999-01-27 CN disclosed
EP-0891978-A2 5H-Thiazolo (3,2-a) pyrimidine derivatives F. HOFFMANN-LA ROCHE AG (CH) 1999-01-20 EP disclosed
EP-0804437-A1 [a]-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USES THEREOF MERCKLE GMBH (DE) 1997-11-05 EP disclosed
EP-0788496-A1 APOLIPOPROTEIN-B SYNTHESIS INHIBITORS JANSSEN PHARMACEUTICA N.V. (BE) 1997-08-13 EP disclosed
WO-1995032971-A1 [a]-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USES THEREOF MERCKLE GMBH (DE) 1995-12-07 WO disclosed