Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.46 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 3/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.52 |
| ▸ | HTR7 | P34969 | 8/20 | 0.51 |
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1185948 | 0.94 | TACR1 (0.54) | TACR1OPRM1HTR7HTR1ADRD2 | |
| Fumaric Acid SCHEMBL1185462 | 0.90 | TACR1 (0.55) | TACR1OPRM1HTR7HTR1ADRD2 | |
| Fumaric Acid SCHEMBL1185797 | 0.86 | TACR1 (0.49) | TACR1OPRM1HTR7MEN1KMT2A | |
| SCHEMBL1186148 | 0.83 | ADRA1D (0.58) | TACR1OPRM1HTR7HTR1ADRD2 | |
| SCHEMBL1186118 | 0.79 | TACR1 (0.51) | TACR1OPRM1HTR7MEN1THRB | |
| Fumaric Acid SCHEMBL1185751 | 0.78 | HTR7 (0.53) | HTR7HTR1ADRD2DRD4 | |
| SCHEMBL1494352 | 0.77 | HTR7 (0.46) | TACR1OPRM1HTR7MEN1KMT2A | |
| SCHEMBL1494526 | 0.77 | HTR7 (0.46) | TACR1OPRM1HTR7MEN1KMT2A | |
| SCHEMBL1494040 | 0.76 | HTR7 (0.45) | TACR1OPRM1HTR7HTR1AMEN1 | |
| SCHEMBL1494387 | 0.75 | HTR7 (0.44) | TACR1OPRM1HTR7MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028490-A1 | 4-PHENYL-PIPERAZIN-1-YL-ALKYL-BENZOIMIDAZOL-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE IN-HIBITORS | NEUROSEARCH A/S (DK) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028490-A1 | 4-PHENYL-PIPERAZIN-1-YL-ALKYL-BENZOIMIDAZOL-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE IN-HIBITORS | SLC18A2, SLC6A2, SLC18A3 | DRD2 262/4885MEN1 2587/4885KMT2A 1410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.