Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11859664 | 0.89 | CSNK1D (0.53) | NPC1RAB9ATSHRMAPK1ALDH1A1 | |
| SCHEMBL11858213 | 0.88 | LMNA (0.55) | TSHRMAPK1ALDH1A1LMNAKDM4E | |
| SCHEMBL11861682 | 0.84 | SMN1; SMN2 (0.50) | NPC1RAB9ATSHRMAPK1ALDH1A1 | |
| SCHEMBL11859880 | 0.84 | ALDH1A1 (0.48) | NPC1RAB9ATSHRMAPK1ALDH1A1 | |
| SCHEMBL11867146 | 0.84 | SMN1; SMN2 (0.51) | NPC1RAB9ATSHRMAPK1ALDH1A1 | |
| SCHEMBL11866139 | 0.83 | RXFP1 (0.47) | NPC1RAB9ATSHRMAPK1ALDH1A1 | |
| SCHEMBL11866621 | 0.81 | CSNK1D (0.51) | NPC1RAB9ATSHRMAPK1ALDH1A1 | |
| SCHEMBL11866685 | 0.80 | CSNK1D (0.49) | NPC1RAB9ATSHRMAPK1ALDH1A1 | |
| SCHEMBL11865108 | 0.78 | CSNK1D (0.48) | NPC1RAB9ATSHRMAPK1ALDH1A1 | |
| SCHEMBL11868125 | 0.78 | NPSR1 (0.46) | NPC1TSHRMAPK1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3992380-A | 5,8-Dihydro-5-oxo-2-(4-or 3-pyridinyl)pyrido[2,3-d]pyrimidine-6-carboxylic acids and esters | STERLING DRUG INC. (US) | 1976-11-16 | — | — | US | disclosed |