Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | FOS | P01100 | 1/20 | 0.50 |
| ▸ | JUN | P05412 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11866621 | 0.92 | CSNK1D (0.51) | CSNK1DSMN1; SMN2RXFP1FOSJUN | |
| SCHEMBL11866685 | 0.90 | CSNK1D (0.49) | CSNK1DSMN1; SMN2RXFP1FOSJUN | |
| SCHEMBL11864239 | 0.89 | DCTPP1 (0.52) | SMN1; SMN2RXFP1MAPK1TSHRALDH1A1 | |
| SCHEMBL11861682 | 0.89 | SMN1; SMN2 (0.50) | SMN1; SMN2RXFP1MAPK1TSHRALDH1A1 | |
| SCHEMBL11872614 | 0.88 | CSNK1D (0.53) | CSNK1DSMN1; SMN2FOSJUNNFKB1 | |
| SCHEMBL11868125 | 0.88 | NPSR1 (0.46) | CSNK1DSMN1; SMN2RXFP1FOSJUN | |
| SCHEMBL11865108 | 0.88 | CSNK1D (0.48) | CSNK1DSMN1; SMN2RXFP1FOSJUN | |
| SCHEMBL11866139 | 0.87 | RXFP1 (0.47) | SMN1; SMN2RXFP1MAPK1TSHRALDH1A1 | |
| SCHEMBL11867032 | 0.87 | LMNA (0.58) | MAPK1TSHRALDH1A1LMNAMEN1 | |
| SCHEMBL11859880 | 0.87 | ALDH1A1 (0.48) | SMN1; SMN2RXFP1MAPK1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3992380-A | 5,8-Dihydro-5-oxo-2-(4-or 3-pyridinyl)pyrido[2,3-d]pyrimidine-6-carboxylic acids and esters | STERLING DRUG INC. (US) | 1976-11-16 | — | — | US | disclosed |