Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11857025 | 0.87 | PDE4A (0.41) | PDE4DPDE5APDE4APDE4BPDE4C | |
| SCHEMBL11165951 | 0.84 | NR1I2 (0.58) | PDE4DNR1I2EGFRADRA2AADORA3 | |
| SCHEMBL11864694 | 0.80 | MAPT (0.44) | CNR2KDM4EALDH1A1HPGD | |
| SCHEMBL11865026 | 0.80 | LMNA (0.37) | PDE4DPDE5APDE4APDE4BPDE4C | |
| SCHEMBL11870097 | 0.79 | PARG (0.38) | PTGS2CNR2CNR1KCNH2 | |
| SCHEMBL11853865 | 0.78 | GRIN1 (0.44) | PDE4DNR1I2EGFRADRA2AADORA3 | |
| SCHEMBL11861502 | 0.78 | ADORA2A (0.42) | PDE4DNR1I2EGFRADRA2AADORA3 | |
| SCHEMBL11635900 | 0.77 | LMNA (0.55) | PDE4DNR1I2EGFRADRA2AADORA3 | |
| SCHEMBL11635741 | 0.75 | NR1I2 (0.49) | PDE4DNR1I2EGFRADRA2AADORA3 | |
| SCHEMBL11857345 | 0.73 | CNR2 (0.42) | CNR2CNR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3950526-A | Quinazoline derivatives in pharmaceutical compositions for treating pain and inflammation | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-04-13 | — | — | US | disclosed |