Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | RORA | P35398 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11865220 | 0.87 | PDE4D (0.41) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11864694 | 0.85 | MAPT (0.44) | CNR2PTGER4KDM4EALDH1A1NPSR1 | |
| SCHEMBL11865026 | 0.85 | LMNA (0.37) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11870097 | 0.84 | PARG (0.38) | CNR2RORC | |
| SCHEMBL11164226 | 0.83 | POLB (0.51) | — | |
| SCHEMBL11857345 | 0.79 | CNR2 (0.42) | CNR2RORARORCRORBNPC1 | |
| SCHEMBL11635900 | 0.79 | LMNA (0.55) | PDE4DPTGER4 | |
| SCHEMBL11863918 | 0.78 | GRIN1 (0.46) | PDE4APDE4BPDE4CPDE4DPTGER4 | |
| SCHEMBL11867581 | 0.78 | ADORA2A (0.43) | KDM4EALDH1A1HSD17B10DHFR | |
| SCHEMBL11867757 | 0.77 | PTGER4 (0.43) | BRD4PTGER4KDM4EALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3950526-A | Quinazoline derivatives in pharmaceutical compositions for treating pain and inflammation | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-04-13 | — | — | US | disclosed |