Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 4/20 | 0.47 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11867140 | 0.81 | MAPT (0.58) | KDM4EALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL11107245 | 0.81 | TTR (0.54) | TTRPGAM1KDM4EALDH1A1MAPT | |
| SCHEMBL497339 | 0.77 | MAPT (0.60) | TTRPGAM1KDM4EALDH1A1MAPT | |
| SCHEMBL29551111 | 0.77 | MAPT (0.60) | TTRPGAM1KDM4EALDH1A1MAPT | |
| SCHEMBL11867376 | 0.77 | PTGDR2 (0.48) | KDM4EMAPTLMNAMEN1KMT2A | |
| SCHEMBL11101186 | 0.73 | TTR (0.72) | TTRPGAM1KDM4EALDH1A1MAPT | |
| SCHEMBL11861191 | 0.73 | MCL1 (0.53) | TTRPGAM1KDM4EALDH1A1MAPT | |
| SCHEMBL27867460 | 0.72 | BACE1 (0.50) | TTRPGAM1KDM4EALDH1A1MAPT | |
| SCHEMBL9095280 | 0.72 | ADORA2A (0.47) | TTRKDM4EALDH1A1MAPTLMNA | |
| SCHEMBL10602479 | 0.72 | MEN1 (0.58) | TTRPGAM1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3976686-A | DIURETIC, SALURETIC, URICOSURIC | MERCK & CO., INC. (US) | 1976-08-24 | — | — | US | disclosed |