SCHEMBL11107245

SCHEMBL11107245

CC(=O)Oc1ccc2c(c1Cl)C(=O)c1ccccc1C2=O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 2/20 0.54
MAPT P10636 9/20 0.51
MEN1 O00255 5/20 0.51
KMT2A Q03164 5/20 0.51
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
SMN1; SMN2 Q16637 4/20 0.49
ALDH1A1 P00352 7/20 0.46
MAPK1 P28482 6/20 0.46
KDM4E B2RXH2 4/20 0.46
HPGD P15428 3/20 0.46
LMNA P02545 3/20 0.46
USP2 O75604 2/20 0.46
ADORA2A P29274 2/20 0.46
ABCC4 O15439 1/20 0.46
TP53 P04637 1/20 0.46
HSP90AA1 P07900 1/20 0.46
CHRM2 P08172 1/20 0.46
HSP90AB1 P08238 1/20 0.46
HTR1A P08908 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8769865 0.86 MAPT (0.49) TTRMAPTMEN1KMT2ANPC1
SCHEMBL3959473 0.83 MAPT (0.69) TTRMAPTMEN1KMT2ANPC1
SCHEMBL4645309 0.83 SMN1; SMN2 (0.58) TTRMAPTMEN1KMT2ANPC1
SCHEMBL497339 0.82 MAPT (0.60) TTRMAPTMEN1KMT2ANPC1
SCHEMBL29551111 0.82 MAPT (0.60) TTRMAPTMEN1KMT2ANPC1
SCHEMBL6902878 0.81 RAB9A (0.68) MAPTMEN1KMT2ANPC1RAB9A
SCHEMBL11101186 0.81 TTR (0.72) TTRMAPTMEN1KMT2ANPC1
SCHEMBL11867382 0.81 TTR (0.47) TTRMAPTMEN1KMT2ANPC1
SCHEMBL20746507 0.79 SMN1; SMN2 (0.49) TTRMAPTMEN1KMT2ANPC1
SCHEMBL11303111 0.75 ADORA2A (0.68) TTRMAPTMEN1KMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4451278-A 1-Hydroxyanthraquinone aquatic herbicide GAF CORPORATION (US) 1984-05-29 US disclosed