SCHEMBL118685

SCHEMBL118685

O=C(O)C(=O)ON1C(=O)CCC1=O

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PARL Q9H300 3/20 0.41
MGLL Q99685 4/20 0.38
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA9 Q16790 1/20 0.33
ALOX12 P18054 1/20 0.32
KMT2A Q03164 3/20 0.31
ATM Q13315 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethylene Glycol SCHEMBL29130624 0.91 PARL (0.36) PARLMGLLALOX12KMT2AATM
SCHEMBL865136 0.90 MGLL (0.40) PARLMGLLCA12CA1CA9
Succinimide SCHEMBL6549250 0.88 CRBN (0.42) PARLMGLL
SCHEMBL28964134 0.84 MGLL (0.36) PARLMGLLCA12CA1CA9
SCHEMBL57128 0.82 PARL (0.38) PARLMGLLCA12CA1CA9
Methacrylic Acid SCHEMBL27191395 0.82 KMT2A (0.44) PARLMGLLKMT2AATM
SCHEMBL28377582 0.81 MGLL (0.36) PARLMGLL
SCHEMBL10889616 0.81 GLA (0.39) PARLMGLLCA12CA1CA9
Bicarbonate SCHEMBL28277653 0.80 MGLL (0.36) PARLMGLLCA12CA1CA9
SCHEMBL1580294 0.80 MGLL (0.38) PARLMGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 508 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3782653-B1 COMPOSITION COMPRISING PEGYLATED ARGININE DEIMINASE POLARIS GROUP (TW) 2025-03-19 EP claimed
CN-115814163-B PEG bi-component self-adhesive absorbable biological patch, and preparation method and application thereof 北京博辉瑞进生物科技有限公司 2023-09-29 CN claimed
EP-3782653-A1 COMPOSITION COMPRISING PEGYLATED ARGININE DEIMINASE Polaris Group (CN) 2021-02-24 EP claimed
EP-2834262-B1 COMPOSITION COMPRISING PEGYLATED ARGININE DEIMINASE POLARIS GROUP (CN) 2020-09-02 EP claimed
CN-109072482-A MULTIVALENT GLYCAN MICROARRAY PLATFORM Z生物科技有限公司 2018-12-21 CN claimed
US-20180154008-A1 METHODS OF TREATMENT WITH ARGININE DEIMINASE POLARIS GROUP (KY) 2018-06-07 US claimed
US-9731028-B2 Methods of treatment with arginine deiminase POLARIS GROUP (KY) 2017-08-15 US claimed
US-20150132278-A1 METHODS OF TREATMENT WITH ARGININE DEIMINASE POLARIS GROUP (TW) 2015-05-14 US claimed
EP-2834262-A1 METHODS OF TREATMENT WITH ARGININE DEIMINASE Polaris Group (CN) 2015-02-11 EP claimed
WO-2013151568-A1 METHODS OF TREATMENT WITH ARGININE DEIMINASE POLARIS GROUP (CN) 2013-10-10 WO claimed
US-6737259-B1 MODIFIED WITH POLYETHYLENE GLYCOL FOR TREATMENT AND INHIBITION OF CANCER AND METASTASIS PHOENIX PHARMACOLOGICS, INC. 2004-05-18 US claimed
EP-1337630-A2 MODIFIED ARGININE DEIMINASE Phoenix Pharmacologics, Inc. (US) 2003-08-27 EP claimed
US-20030082786-A1 Compound for use in the treatment of gout and tumors SHENYANG SUNSHINE PHARMACEUTICAL COMPANY LIMITED (CN) 2003-05-01 US claimed
WO-2003011211-A2 PEG-MODIFIED URICASE PHOENIX PHARMACOLOGICS, INC. (US) 2003-02-13 WO claimed
WO-2002044360-A2 MODIFIED ARGININE DEIMINASE PHOENIX PHARMACOLOGICS, INC. (US) 2002-06-06 WO claimed
JP-2001524836-A 2001-12-04 JP claimed
US-6183738-B1 COVALENTLY BONDED TO POLYOXYETHYLENE GLYCOL VIA SUCCINIMIDE-TYPE LINKER; ANTITUMOR, ANTICARCINOGENIC, AND ANTIMETASTASIS AGENTS PHOENIX PHARAMACOLOGICS, INC. 2001-02-06 US claimed
EP-0981607-A1 MODIIFIED ARGININE DEIMINASE Phoenix Pharmacologics, Inc. (US) 2000-03-01 EP claimed
WO-1998051784-A1 MODIIFIED ARGININE DEIMINASE PHOENIX PHARMACOLOGICS, INC. (US) 1998-11-19 WO claimed
US-5446134-A Reacting bis(fluorosulfonyl)methane salt with cyanogen halide or pseudohalide CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 1995-08-29 US claimed