Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.36 |
| ▸ | PARL | Q9H300 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17447 | 0.95 | MGLL (0.37) | MGLLPARLCA12CA1CA9 | |
| Ethylene Glycol SCHEMBL8522385 | 0.86 | MGLL (0.33) | MGLLPARLALOX12 | |
| SCHEMBL2139612 | 0.85 | MGLL (0.35) | MGLLPARL | |
| SCHEMBL28388369 | 0.84 | PARL (0.33) | MGLLPARLALOX12 | |
| SCHEMBL5570883 | 0.83 | PARL (0.35) | MGLLPARL | |
| SCHEMBL19928412 | 0.82 | MGLL (0.35) | MGLLPARL | |
| SCHEMBL8402012 | 0.82 | MGLL (0.32) | MGLL | |
| SCHEMBL57128 | 0.82 | PARL (0.38) | MGLLPARLCA12CA1CA9 | |
| SCHEMBL3276680 | 0.82 | MGLL (0.36) | MGLLPARLCA12CA1CA9 | |
| Pyridine SCHEMBL3849496 | 0.82 | PARL (0.37) | MGLLPARLCA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105037523-B | Interferon mutant and its polyethyleneglycol derivative | 北京三元基因药业股份有限公司 | 2019-02-19 | — | — | CN | disclosed |