SCHEMBL118727

SCHEMBL118727

Nc1ccc2[nH]c(=O)oc2c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS1 P29475 4/20 0.61
PSMB8 P28062 1/20 0.61
OGT O15294 1/20 0.53
PDE3B Q13370 2/20 0.53
PDE3A Q14432 2/20 0.53
KDM4E B2RXH2 2/20 0.50
ALDH1A1 P00352 2/20 0.50
KMO O15229 1/20 0.50
CREBBP Q92793 1/20 0.50
NOS3 P29474 3/20 0.47
NOS2 P35228 3/20 0.47
LMNA P02545 1/20 0.47
CYP1A2 P05177 1/20 0.47
ADRA2A P08913 1/20 0.47
TSHR P16473 1/20 0.47
THPO P40225 1/20 0.47
BLM P54132 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
ALPL P05186 1/20 0.45
SMYD3 Q9H7B4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL221802 0.84 NOS1 (0.61) NOS1PSMB8OGTPDE3BPDE3A
SCHEMBL29748363 0.84 NOS1 (0.61) NOS1PSMB8OGTPDE3BPDE3A
SCHEMBL8777948 0.77 KDM4E (0.50) NOS1PSMB8OGTKDM4EALDH1A1
SCHEMBL1147630 0.77 F2 (0.56) KMT2ASMN1; SMN2NPC1MAPTRAB9A
SCHEMBL6023537 0.77 NOS1 (0.53) NOS1OGTPDE3BPDE3AKDM4E
SCHEMBL8131111 0.76 NOS1 (0.61) NOS1OGTPDE3BPDE3AKDM4E
SCHEMBL1519891 0.76 NOS1 (0.72) NOS1PSMB8OGTPDE3BPDE3A
SCHEMBL11597370 0.76 NOS1 (0.61) NOS1OGTPDE3BPDE3AKDM4E
SCHEMBL993598 0.76 NOS1 (0.61) NOS1OGTPDE3BPDE3AKDM4E
SCHEMBL118671 0.76 PSMB8 (1.00) NOS1PSMB8KDM4EALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 516 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260053786-A1 FORMULATIONS OF RADIPRODIL GRIN THERAPEUTICS INC (US) 2026-02-26 US claimed
US-20250288518-A1 METHODS OF USING RADIPRODIL IN THE TREATMENT OF DISORDERS GRIN THERAPEUTICS, INC. 2025-09-18 US claimed
WO-2025137652-A2 METHODS OF USING RADIPRODIL IN THE TREATMENT OF DISORDERS GRIN THERAPEUTICS, INC. (US) 2025-06-26 WO claimed
US-20250127770-A1 FORMULATIONS OF RADIPRODIL GRIN THERAPEUTICS, INC. 2025-04-24 US claimed
EP-4380547-A1 FORMULATIONS OF RADIPRODIL Grin Therapeutics, Inc. (US) 2024-06-12 EP claimed
CN-118019521-A Preparation of raldil 格林治疗股份有限公司 2024-05-10 CN claimed
WO-2023014956-A9 FORMULATIONS OF RADIPRODIL GRIN THERAPEUTICS, INC. (US) 2023-12-14 WO claimed
WO-2023014956-A1 FORMULATIONS OF RADIPRODIL GRIN THERAPEUTICS, INC. (US) 2023-02-09 WO claimed
CN-105018506-A Hydrolase of benzoxazolone compound, gene for coding hydrolase and engineering strain containing gene and application thereof UNIV NANJING AGRICULTURAL 2015-11-04 CN claimed
EP-2414346-B1 AUTOTAXIN INHIBITORS MERCK PATENT GMBH (DE) 2015-06-24 EP claimed
WO-2010025871-A1 4-HALOGEN ALKYL-SUBSTITUTED DIAMINOPYRIMIDINES FOR USE AS FUNGICIDES BAYER CROPSCIENCE AG (DE) 2010-03-11 WO claimed
WO-2010025863-A2 4-ALKYL-SUBSTITUTED DIAMINOPYRIMIDINES BAYER CROPSCIENCE AG (DE) 2010-03-11 WO claimed
EP-2161259-A1 4-Haloalkyl substituted Diaminopyrimidine Bayer CropScience AG (DE) 2010-03-10 EP claimed
CN-101621927-A Diaminopyrimidines as fungicides BAYER CROPSCIENCE AG 2010-01-06 CN claimed
EP-2129222-A1 DIAMINOPYRIMIDINES AS FUNGICIDES Bayer CropScience AG (DE) 2009-12-09 EP claimed
WO-2009115267-A2 DIAMINOPYRIMIDINES AS PLANT PROTECTION AGENTS BAYER CROPSCIENCE AG (DE) 2009-09-24 WO claimed
WO-2008107096-A1 DIAMINOPYRIMIDINES AS FUNGICIDES BAYER CROPSCIENCE AG (DE) 2008-09-12 WO claimed
US-4997920-A Dyeing polyolefins CIBA-GEIGY CORPORATION (US) 1991-03-05 US claimed
US-4670486-A Polymer composition pigmented with copper or nickel complexes of ligands containing a semicarbazone moiety CIBA-GEIGY CORPORATION (US) 1987-06-02 US claimed
EP-0086126-B1 IMIDAZOLINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTICAL APPLICATION SYNTHELABO (FR) 1985-07-24 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260053786-A1 FORMULATIONS OF RADIPRODIL GRIN2D, GRIN2A, GRIN2B NOS1 2825/4885PSMB8 3443/4885OGT 4419/4885
US-20250288518-A1 METHODS OF USING RADIPRODIL IN THE TREATMENT OF DISORDERS CLN6, GABARAPL2, GABARAPL1 NOS1 4459/4885PSMB8 2522/4885OGT 3416/4885
US-20250127770-A1 FORMULATIONS OF RADIPRODIL GABARAPL2, PARL, GABARAPL1 NOS1 4222/4885PSMB8 2730/4885OGT 3137/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.