Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11872380 | 0.82 | TSHR (0.51) | TSHRALDH1A1HSD17B10L3MBTL1BCHE | |
| SCHEMBL11878613 | 0.79 | TSHR (0.50) | TSHRALDH1A1ATMLMNAL3MBTL1 | |
| SCHEMBL11878248 | 0.79 | PDE4B (0.35) | ALDH1A1L3MBTL1ACHE | |
| SCHEMBL11877618 | 0.78 | ALDH1A1 (0.43) | TSHRCYP1B1ALDH1A1HSD17B10LMNA | |
| SCHEMBL11852039 | 0.77 | TSHR (0.62) | TRPA1TSHRALDH1A1HSD17B10LMNA | |
| SCHEMBL11873522 | 0.77 | TRPA1 (0.40) | TRPA1TSHRCYP1B1BRD4CREBBP | |
| SCHEMBL11871416 | 0.75 | ALDH1A1 (0.45) | ALDH1A1LMNABCHECES1POLB | |
| SCHEMBL11841114 | 0.72 | TSHR (0.59) | TRPA1TSHRCYP1B1ALDH1A1HSD17B10 | |
| SCHEMBL5424486 | 0.70 | CES1 (0.62) | TRPA1ALDH1A1BCHECES1TGM2 | |
| Maleic Acid SCHEMBL11840695 | 0.70 | TSHR (0.54) | TRPA1TSHRALDH1A1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3984556-A | Alkyl-substituted-tricyclic quinazolinones for lowering blood pressure | SANDOZ, INC. (US) | 1976-10-05 | — | — | US | disclosed |
| US-3982000-A | Alkyl-substituted-tricyclic quinazolinones as bronchodilators | SANDOZ, INC. (US) | 1976-09-21 | — | — | US | disclosed |