Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL11840713 | 1.00 | TSHR (0.54) | TSHRTRPA1ALDH1A1GAAGFER | |
| SCHEMBL11852039 | 0.91 | TSHR (0.62) | TSHRTRPA1ALDH1A1GAAGFER | |
| SCHEMBL11841114 | 0.85 | TSHR (0.59) | TSHRTRPA1ALDH1A1GAAGFER | |
| SCHEMBL2493279 | 0.75 | TSHR (0.83) | TSHRALDH1A1GAAGFERLMNA | |
| SCHEMBL2494160 | 0.75 | TSHR (0.67) | TSHRALDH1A1GAAGFERLMNA | |
| SCHEMBL11848745 | 0.74 | TSHR (0.57) | TSHRTRPA1ALDH1A1GAAGFER | |
| SCHEMBL11809473 | 0.74 | TSHR (0.45) | TSHRALDH1A1GAAGFERLMNA | |
| SCHEMBL11751040 | 0.71 | TSHR (0.56) | TSHRALDH1A1GAAGFERLMNA | |
| SCHEMBL11845293 | 0.70 | TSHR (1.00) | TSHRGAAGFERLMNAMEN1 | |
| SCHEMBL11842041 | 0.70 | TSHR (0.60) | TSHRALDH1A1GAAGFERLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3969506-A | BRONCHODILATOR | SANDOZ, INC. (US) | 1976-07-13 | — | — | US | disclosed |