Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11878613 | 0.82 | TSHR (0.50) | SMN1; SMN2ACHEBCHETP53KMT2A | |
| SCHEMBL11878248 | 0.80 | PDE4B (0.35) | ACHEPDE4BFGFR1FGFR4KMT2A | |
| SCHEMBL11872380 | 0.72 | TSHR (0.51) | SMN1; SMN2ACHEBCHEMAPTKMT2A | |
| SCHEMBL11845463 | 0.70 | TSHR (0.57) | SMN1; SMN2ACHEBCHETP53KMT2A | |
| SCHEMBL11846111 | 0.62 | TSHR (0.68) | TP53KMT2ATSHRHTTMEN1 | |
| SCHEMBL10799560 | 0.61 | TSHR (0.34) | BCHEKMT2ATSHRHTTMEN1 | |
| SCHEMBL31658284 | 0.61 | CA12 (0.46) | ACHEBCHETP53MAPTKMT2A | |
| SCHEMBL10796193 | 0.60 | PDE4A (0.38) | SMN1; SMN2BCHEMAPTKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL11877009 | 0.60 | CASP3 (0.45) | ACHEBCHEKMT2AALDH1A1TSHR | |
| SCHEMBL11879082 | 0.60 | TSHR (0.47) | ACHEBCHEPTGDR2KMT2AHCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3984556-A | Alkyl-substituted-tricyclic quinazolinones for lowering blood pressure | SANDOZ, INC. (US) | 1976-10-05 | — | — | US | disclosed |
| US-3982000-A | Alkyl-substituted-tricyclic quinazolinones as bronchodilators | SANDOZ, INC. (US) | 1976-09-21 | — | — | US | disclosed |