Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | APP | P05067 | 2/20 | 0.45 |
| ▸ | SNCA | P37840 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11873165 | 0.84 | TSHR (0.51) | TSHRKMT2ALMNAPTGDR2 | |
| SCHEMBL11850698 | 0.80 | TSHR (0.59) | MAPTAPPSNCATSHRUTS2R | |
| SCHEMBL11847929 | 0.77 | TSHR (0.60) | MAPTAPPSNCATSHRUTS2R | |
| SCHEMBL4854039 | 0.70 | NR1H3 (0.62) | MAPTUTS2RKMT2ANR1H3TP53 | |
| SCHEMBL11800639 | 0.69 | RXFP1 (0.48) | MAPTTSHRUTS2RKMT2ATP53 | |
| SCHEMBL11877099 | 0.68 | P2RX7 (0.53) | TSHRPTGDR2SCN9A | |
| Hydrochloric Acid SCHEMBL11851095 | 0.67 | TSHR (0.73) | MAPTAPPSNCATSHRKMT2A | |
| SCHEMBL11881664 | 0.66 | P2RX7 (0.51) | TSHRKMT2ALMNA | |
| SCHEMBL11871825 | 0.66 | CHRM1 (0.53) | TSHRLMNAALDH1A1 | |
| SCHEMBL11845463 | 0.65 | TSHR (0.57) | APPTSHRUTS2RKMT2AABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3984556-A | Alkyl-substituted-tricyclic quinazolinones for lowering blood pressure | SANDOZ, INC. (US) | 1976-10-05 | — | — | US | disclosed |
| US-3982000-A | Alkyl-substituted-tricyclic quinazolinones as bronchodilators | SANDOZ, INC. (US) | 1976-09-21 | — | — | US | disclosed |