Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5489927 | 0.90 | HRH3 (0.52) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL11179141 | 0.90 | HRH3 (0.52) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL5319576 | 0.88 | KEAP1 (0.47) | HRH3MAPK1SMN1; SMN2ALDH1A1SIGMAR1 | |
| SCHEMBL10846103 | 0.87 | HRH3 (0.48) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL7225776 | 0.84 | HRH3 (0.54) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL9305861 | 0.81 | HRH3 (0.46) | HRH3TSHR | |
| SCHEMBL643893 | 0.79 | HRH3 (0.48) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL5248213 | 0.79 | HRH3 (0.42) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL750128 | 0.76 | HRH3 (0.56) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL15658696 | 0.76 | HRH3 (0.44) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971604-B1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | AMGEN INC (US) | 2012-08-01 | — | — | EP | disclosed |