Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL643893 | 0.95 | HRH3 (0.48) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL5419101 | 0.86 | KEAP1 (0.47) | HRH3CYP1A2MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7543987 | 0.86 | CXCR4 (0.53) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL11889486 | 0.84 | HRH3 (0.56) | HRH3CYP1A2MAPK1SMN1; SMN2MAPT | |
| SCHEMBL5498783 | 0.80 | PAOX (0.41) | HRH3MAPTALDH1A1SIGMAR1 | |
| SCHEMBL4526651 | 0.78 | KEAP1 (0.52) | HRH3CYP1A2MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5499197 | 0.78 | CXCR4 (0.48) | HRH3CYP1A2SMN1; SMN2SIGMAR1POLB | |
| SCHEMBL9412671 | 0.77 | HRH3 (0.32) | HRH3SMN1; SMN2 | |
| SCHEMBL1400000 | 0.77 | HRH3 (0.43) | HRH3SMN1; SMN2MAPTCARM1PRMT6 | |
| SCHEMBL11833413 | 0.77 | SIGMAR1 (0.40) | HRH3CYP1A2MAPTCARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514971-B1 | For use in the production of antiangiogenic and/or vascular permeability reducing effects in warm-blooded animals such as humans | ZENECA LIMITED (GB) | 2003-02-04 | — | — | US | disclosed |