Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27926443 | 0.89 | KMT2A (0.44) | KMT2AMEN1ADORA3THRBCHRM1 | |
| SCHEMBL11388942 | 0.83 | SRC (0.54) | KMT2AMEN1ADORA3THRBCHRM1 | |
| SCHEMBL29385679 | 0.78 | KMT2A (0.50) | KMT2AMEN1SRCHDAC4HDAC2 | |
| SCHEMBL4120437 | 0.78 | KMT2A (0.50) | KMT2AMEN1SRCHDAC4HDAC2 | |
| Diphenylacetic Acid SCHEMBL8513250 | 0.76 | SRC (0.62) | KMT2AMEN1ADORA3THRBCHRM1 | |
| Diphenylacetic Acid SCHEMBL38022 | 0.76 | SRC (0.62) | KMT2AMEN1ADORA3THRBCHRM1 | |
| SCHEMBL4886483 | 0.76 | LMNA (0.50) | KMT2AMEN1L3MBTL1HDAC4HDAC2 | |
| SCHEMBL11363822 | 0.76 | MEN1 (0.50) | KMT2AMEN1TDP1L3MBTL1CYP2D6 | |
| SCHEMBL4538108 | 0.75 | PTGS2 (0.61) | TDP1L3MBTL1CYP2D6SRCHDAC3 | |
| Diphenylacetic Acid SCHEMBL3885595 | 0.75 | HNF4A (0.50) | KMT2AMEN1SRCBCAT2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016039-B1 | TERPHENYL DERIVATIVES FOR TREATMENT OF ALZHEIMER' S DISEASE | ORTHO MCNEIL JANSSEN PHARM (US) | 2012-08-01 | — | — | EP | disclosed |