Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.75 |
| ▸ | DRD2 | P14416 | 6/20 | 0.75 |
| ▸ | DRD4 | P21917 | 4/20 | 0.75 |
| ▸ | DRD3 | P35462 | 3/20 | 0.75 |
| ▸ | HTR2B | P41595 | 2/20 | 0.75 |
| ▸ | HTR2A | P28223 | 1/20 | 0.75 |
| ▸ | HTR7 | P34969 | 1/20 | 0.75 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adoprazine SCHEMBL29522743 | 0.85 | DRD2 (1.00) | HTR1ADRD2DRD4DRD3HTR2B | |
| Adoprazine SCHEMBL678503 | 0.85 | DRD2 (1.00) | HTR1ADRD2DRD4DRD3HTR2B | |
| Adoprazine SCHEMBL4179481 | 0.85 | DRD2 (1.00) | HTR1ADRD2DRD4DRD3HTR2B | |
| SCHEMBL13239021 | 0.80 | HTR1A (0.70) | HTR1ADRD2DRD4DRD3HTR2B | |
| SCHEMBL13239020 | 0.80 | HTR1A (0.70) | HTR1ADRD2DRD4DRD3HTR2B | |
| SCHEMBL13533046 | 0.77 | HTR1A (0.83) | HTR1ADRD2DRD4DRD3HTR2B | |
| SCHEMBL13533042 | 0.75 | HTR1A (0.68) | HTR1ADRD2DRD4DRD3HTR2B | |
| SCHEMBL13533015 | 0.73 | HTR1A (0.81) | HTR1ADRD2 | |
| SCHEMBL4186412 | 0.72 | HTR1A (0.70) | HTR1ADRD2DRD4DRD3HTR2B | |
| SCHEMBL13533033 | 0.72 | HTR1A (0.67) | HTR1ADRD2DRD4DRD3HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024363-B1 | N-OXIDES OF PYRIDYLMETHYLPIPERAZINE AND -PIPERIDINE DERIVATIVES | ABBOTT HEALTHCARE PRODUCTS BV (NL) | 2012-08-01 | — | — | EP | claimed |