Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adoprazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 11/20 | 1.00 |
| ▸ | HTR1A known ✓ | P08908 | 7/20 | 1.00 |
| ▸ | DRD3 known ✓ | P35462 | 7/20 | 0.98 |
| ▸ | DRD4 | P21917 | 8/20 | 0.98 |
| ▸ | HTR2B | P41595 | 2/20 | 0.98 |
| ▸ | HTR2A | P28223 | 1/20 | 0.98 |
| ▸ | HTR7 | P34969 | 1/20 | 0.98 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adoprazine SCHEMBL678503 | 0.99 | DRD2 (1.00) | DRD2HTR1ADRD4DRD3HTR2B | |
| Adoprazine SCHEMBL29522743 | 0.99 | DRD2 (1.00) | DRD2HTR1ADRD4DRD3HTR2B | |
| SCHEMBL13533046 | 0.87 | HTR1A (0.83) | DRD2HTR1ADRD4DRD3HTR2B | |
| SCHEMBL11890171 | 0.85 | HTR1A (0.75) | DRD2HTR1ADRD4DRD3HTR2B | |
| SCHEMBL5652820 | 0.83 | HTR1A (0.73) | DRD2HTR1ADRD4DRD3HTR2B | |
| Hydrochloric Acid SCHEMBL7987675 | 0.83 | DRD2 (0.73) | DRD2HTR1ADRD4DRD3HTR2B | |
| Hydrochloric Acid SCHEMBL27449674 | 0.83 | DRD2 (0.73) | DRD2HTR1ADRD4DRD3HTR2B | |
| SCHEMBL4178305 | 0.83 | DRD2 (0.70) | DRD2HTR1ADRD4DRD3HTR2B | |
| SCHEMBL4179541 | 0.82 | HTR1A (0.70) | DRD2HTR1ADRD4DRD3HTR2B | |
| SCHEMBL17471564 | 0.82 | HTR1A (0.70) | DRD2HTR1ADRD4DRD3HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024363-A1 | N-OXIDES OF PYRIDYLMETHYLPIPERAZINE AND -PIPERIDINE DERIVATIVES | Solvay Pharmaceuticals B.V. (NL) | 2009-02-18 | — | — | EP | disclosed |
| US-20070275977-A1 | N-OXIDES OF PYRIDYLMETHYL -PIPERAZINE AND -PIPERIDINE DERIVATIVES | SOLVAY PHARMACEUTICALS B.V. (NL) | 2007-11-29 | — | — | US | disclosed |
| WO-2007128694-A1 | N-OXIDES OF PYRIDYLMETHYLPIPERAZINE AND -PIPERIDINE DERIVATIVES | SOLVAY PHARMACEUTICALS B.V. (NL) | 2007-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275977-A1 | N-OXIDES OF PYRIDYLMETHYL -PIPERAZINE AND -PIPERIDINE DERIVATIVES | CHRM5, HTR5A, CHRNA5 | DRD2 55/4885HTR1A 41/4885DRD3 92/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.