Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | GNRHR | P30968 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15099942 | 1.00 | HPGD (0.44) | HPGDALDH1A1KDM4ECYP2D6CYP2C9 | |
| SCHEMBL11893590 | 1.00 | HPGD (0.44) | HPGDALDH1A1KDM4ECYP2D6CYP2C9 | |
| SCHEMBL11893667 | 0.81 | MEN1 (0.40) | HPGDALDH1A1CYP2D6CYP2C9HSD17B10 | |
| SCHEMBL11893668 | 0.81 | MEN1 (0.40) | HPGDALDH1A1CYP2D6CYP2C9HSD17B10 | |
| SCHEMBL12799202 | 0.81 | MEN1 (0.40) | HPGDALDH1A1CYP2D6CYP2C9HSD17B10 | |
| SCHEMBL11894337 | 0.81 | ALDH1A1 (0.56) | ALDH1A1CYP2D6NPC1RAB9AMEN1 | |
| SCHEMBL11894339 | 0.81 | ALDH1A1 (0.56) | ALDH1A1CYP2D6NPC1RAB9AMEN1 | |
| SCHEMBL12798282 | 0.81 | ALDH1A1 (0.56) | ALDH1A1CYP2D6NPC1RAB9AMEN1 | |
| SCHEMBL1666506 | 0.80 | ALDH1A1 (0.48) | HPGDALDH1A1KDM4EHSD17B10NPC1 | |
| SCHEMBL12798265 | 0.80 | ALDH1A1 (0.48) | HPGDALDH1A1KDM4EHSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865704-B2 | Wnt pathway antagonists | SIENA BIOTECH S.P.A. (IT) | 2014-10-21 | — | — | US | disclosed |
| US-8865704-B2 | Wnt pathway antagonists | SIENA BIOTECH S.P.A. (IT) | 2014-10-21 | — | — | US | disclosed |
| EP-2485728-B1 | WNT PATHWAY ANTAGONISTS | SIENA BIOTECH SPA (IT) | 2013-07-10 | — | — | EP | disclosed |
| EP-2485728-B1 | WNT PATHWAY ANTAGONISTS | SIENA BIOTECH SPA (IT) | 2013-07-10 | — | — | EP | disclosed |
| US-20120196851-A1 | WNT PATHWAY ANTAGONISTS | SIENA BIOTECH S.P.A. (IT) | 2012-08-02 | — | — | US | disclosed |
| US-20120196851-A1 | WNT PATHWAY ANTAGONISTS | SIENA BIOTECH S.P.A. (IT) | 2012-08-02 | — | — | US | disclosed |
| US-20120196851-A1 | WNT PATHWAY ANTAGONISTS | SIENA BIOTECH S.P.A. (IT) | 2012-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196851-A1 | WNT PATHWAY ANTAGONISTS | WNT1, WNT3A, CTNNB1 | HPGD 1628/4885ALDH1A1 1797/4885KDM4E 3425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.