Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | ME2 | P23368 | 1/20 | 0.33 |
| ▸ | ME1 | P48163 | 1/20 | 0.33 |
| ▸ | ME3 | Q16798 | 1/20 | 0.33 |
| ▸ | NT5E | P21589 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1680192 | 0.85 | ME2 (0.43) | DYRK1ANPC1RAB9AME2ME1 | |
| Hydrochloric Acid SCHEMBL5534014 | 0.83 | ME2 (0.42) | DYRK1ANPC1RAB9AME2ME1 | |
| Hydrochloric Acid SCHEMBL15769036 | 0.82 | ME2 (0.41) | DYRK1ANPC1RAB9AME2ME1 | |
| SCHEMBL4410281 | 0.78 | ESR2 (0.56) | NPC1RAB9AME2ME1ME3 | |
| SCHEMBL11692690 | 0.77 | DYRK1A (0.50) | TNFDYRK1ANPC1RAB9ACYP11B1 | |
| SCHEMBL433808 | 0.73 | DYRK1A (0.49) | DYRK1ANPC1RAB9ATP53 | |
| SCHEMBL498496 | 0.72 | CYP1B1 (0.42) | NPC1RAB9A | |
| SCHEMBL7261654 | 0.71 | CYP19A1 (0.41) | NPC1RAB9APOLBAPPTP53 | |
| SCHEMBL499169 | 0.71 | PDE4A (0.44) | NPC1RAB9AL3MBTL1 | |
| SCHEMBL4266561 | 0.70 | ME2 (0.34) | NPC1RAB9AME2ME1ME3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431117-B2 | Sickled erythrocytes with anti-tumor agents induce tumor vaso-occlusion and tumoricidal effects | TERMAN DAVID S (US) | 2013-04-30 | — | — | US | disclosed |
| US-20120195869-A1 | Sickled Erythrocytes with Anti-tumor Agents Induce Tumor Vaso-occlusion and Tumoricidal Effects | TERMAN DAVID S (US) | 2012-08-02 | — | — | US | disclosed |