Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.57 |
| ▸ | MTOR | P42345 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11900791 | 1.00 | PIK3CA (0.57) | PIK3CAMTORKDM4ELMNAMAPT | |
| SCHEMBL1444102 | 0.82 | GAA (0.53) | PIK3CAMTORKDM4ELMNAMAPT | |
| SCHEMBL1444110 | 0.82 | GAA (0.53) | PIK3CAMTORKDM4ELMNAMAPT | |
| SCHEMBL1443116 | 0.81 | PIK3CA (0.46) | PIK3CAMTORKDM4ELMNAMAPT | |
| SCHEMBL1443109 | 0.81 | PIK3CA (0.46) | PIK3CAMTORKDM4ELMNAMAPT | |
| SCHEMBL1822331 | 0.72 | PIK3CA (1.00) | PIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL302528 | 0.70 | MAPT (0.39) | PIK3CAKDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL1444466 | 0.70 | GAA (0.54) | PIK3CAKDM4ELMNAMAPTSENP7 | |
| SCHEMBL1444477 | 0.70 | GAA (0.54) | PIK3CAKDM4ELMNAMAPTSENP7 | |
| SCHEMBL6651425 | 0.70 | POLB (0.64) | PIK3CAMTORKDM4ELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120202806-A1 | Novel Pyrimidine- And Triazine-Hepcidine Antagonists | VIFOR (INTERNATIONAL) AG (CH) | 2012-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202806-A1 | Novel Pyrimidine- And Triazine-Hepcidine Antagonists | HAMP, DHPS, SLC40A1 | PIK3CA 3070/4885MTOR 2040/4885KDM4E 3527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.