Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.48 |
| ▸ | CBFB | Q13951 | 2/20 | 0.48 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | GUSB | P08236 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903468 | 0.89 | TRPV1 (0.74) | TRPV1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11903494 | 0.88 | TRPV1 (0.62) | TRPV1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11903440 | 0.88 | TRPV1 (0.58) | TRPV1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11903647 | 0.88 | TRPV1 (0.62) | TRPV1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11903477 | 0.87 | TRPV1 (0.57) | TRPV1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11903467 | 0.86 | TRPV1 (0.57) | TRPV1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11903515 | 0.84 | TRPV1 (0.58) | TRPV1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13305849 | 0.84 | TRPV1 (0.55) | TRPV1CHEK2CBFBRUNX1 | |
| SCHEMBL11903531 | 0.84 | TRPV1 (0.58) | TRPV1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1664917 | 0.83 | CHEK2 (0.56) | TRPV1KDM4ECHEK2RUNX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293780-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | U.S. DEPARTMENT OF ENERGY (US) | 2012-10-23 | — | — | US | disclosed |
| US-8242284-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 2012-08-14 | — | — | US | disclosed |