Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 2/20 | 0.50 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CBFB | Q13951 | 3/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903493 | 0.88 | RUNX1 (0.58) | RHEBRUNX1PDE10ATDP1CBFB | |
| SCHEMBL23389133 | 0.85 | PDE10A (0.46) | RHEBRUNX1PDE10AKDM4EGAA | |
| SCHEMBL10284435 | 0.85 | DDAH1 (0.49) | RUNX1PDE10AKDM4EGAAKMT2A | |
| SCHEMBL19494108 | 0.85 | KDM4E (0.45) | RHEBRUNX1PDE10AKDM4EGAA | |
| SCHEMBL25987878 | 0.83 | PDE10A (0.50) | RHEBRUNX1PDE10AKDM4EGAA | |
| SCHEMBL11903503 | 0.83 | PDE10A (0.50) | RUNX1PDE10AKDM4EGAAKMT2A | |
| SCHEMBL11904657 | 0.82 | PDE10A (0.44) | RHEBRUNX1PDE10AKDM4EGAA | |
| SCHEMBL16189003 | 0.82 | PKM (0.51) | RUNX1PDE10AKDM4EGAAKMT2A | |
| Hydrochloric Acid SCHEMBL11903446 | 0.81 | GRIN1 (0.52) | RUNX1PDE10AGAANPC1LMNA | |
| Hydrochloric Acid SCHEMBL11903592 | 0.81 | GAA (0.56) | RUNX1PDE10AKDM4EGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293780-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | U.S. DEPARTMENT OF ENERGY (US) | 2012-10-23 | — | — | US | disclosed |
| US-8242284-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 2012-08-14 | — | — | US | disclosed |