Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.59 |
| ▸ | RUNX1 | Q01196 | 4/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | GUSB | P08236 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | CBFB | Q13951 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903534 | 0.92 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DRUNX1 | |
| SCHEMBL14382293 | 0.80 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DPRMT5 | |
| SCHEMBL11903517 | 0.79 | RUNX1 (0.52) | RUNX1TRPV1ALOX5EPHX2KDM4E | |
| SCHEMBL6520239 | 0.79 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPRMT5 | |
| SCHEMBL11903647 | 0.78 | TRPV1 (0.62) | RUNX1TRPV1CHEK2GUSBCBFB | |
| SCHEMBL11903477 | 0.77 | TRPV1 (0.57) | RUNX1TRPV1CHEK2CBFBKDM4E | |
| SCHEMBL11903487 | 0.76 | CYP1A2 (0.54) | RUNX1TRPV1KDM4EALDH1A1NPC1 | |
| SCHEMBL10370946 | 0.75 | CYP2E1 (0.49) | RUNX1NPC1PKMRAB9ASMN1; SMN2 | |
| SCHEMBL10372398 | 0.74 | RUNX1 (0.38) | RUNX1ALDH1A1HPGD | |
| SCHEMBL7786898 | 0.73 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293780-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | U.S. DEPARTMENT OF ENERGY (US) | 2012-10-23 | — | — | US | disclosed |
| US-8242284-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 2012-08-14 | — | — | US | disclosed |