Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.57 |
| ▸ | RUNX1 | Q01196 | 4/20 | 0.54 |
| ▸ | CBFB | Q13951 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.52 |
| ▸ | RELA | Q04206 | 2/20 | 0.52 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.52 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903481 | 0.89 | TRPV1 (0.72) | TRPV1RUNX1CBFBNPC1RAB9A | |
| SCHEMBL11903464 | 0.87 | TRPV1 (0.60) | TRPV1RUNX1CBFBNPC1RAB9A | |
| SCHEMBL11903494 | 0.86 | TRPV1 (0.62) | TRPV1RUNX1CBFBNPC1RAB9A | |
| SCHEMBL11903440 | 0.86 | TRPV1 (0.58) | TRPV1RUNX1CBFBNPC1RAB9A | |
| SCHEMBL11903647 | 0.86 | TRPV1 (0.62) | TRPV1RUNX1CBFBNPC1RAB9A | |
| SCHEMBL11903463 | 0.85 | KDM4E (0.61) | TRPV1RUNX1CBFBNPC1RAB9A | |
| SCHEMBL11903467 | 0.85 | TRPV1 (0.57) | TRPV1RUNX1CBFBNPC1RAB9A | |
| SCHEMBL1664917 | 0.84 | CHEK2 (0.56) | TRPV1RUNX1KDM4EALDH1A1HPGD | |
| SCHEMBL11903487 | 0.84 | CYP1A2 (0.54) | TRPV1RUNX1NPC1RAB9AKDM4E | |
| SCHEMBL11903531 | 0.83 | TRPV1 (0.58) | TRPV1RUNX1CBFBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293780-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | U.S. DEPARTMENT OF ENERGY (US) | 2012-10-23 | — | — | US | disclosed |
| US-8242284-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 2012-08-14 | — | — | US | disclosed |