Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.67 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.58 |
| ▸ | GUSB | P08236 | 1/20 | 0.55 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MGAM | O43451 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12848892 | 0.91 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DAMY1A | |
| SCHEMBL12470605 | 0.86 | ALOX5 (0.70) | AMY1AGUSBALOX5EPHX2NPC1 | |
| SCHEMBL30445866 | 0.81 | COMT (0.67) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL25209809 | 0.81 | COMT (0.67) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL14382293 | 0.81 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DAMY1A | |
| SCHEMBL11903534 | 0.79 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DALOX5 | |
| SCHEMBL11903530 | 0.79 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DGUSB | |
| SCHEMBL484162 | 0.79 | CHEK2 (0.57) | PRMT5ALOX5NPC1RAB9AKDM4E | |
| SCHEMBL5756185 | 0.79 | TSHR (0.56) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL12470982 | 0.78 | PRMT5 (0.70) | PRMT5ALOX5NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895599-B2 | Lipoprotein lipase-activating compositions comprising benzene derivates | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2014-11-25 | — | — | US | disclosed |
| US-8895599-B2 | Lipoprotein lipase-activating compositions comprising benzene derivates | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2014-11-25 | — | — | US | disclosed |
| US-20130296342-A1 | LIPOPROTEIN LIPASE-ACTIVATING COMPOSITIONS COMPRISING BENZENE DERIVATES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2013-11-07 | — | — | US | disclosed |
| US-20130296342-A1 | LIPOPROTEIN LIPASE-ACTIVATING COMPOSITIONS COMPRISING BENZENE DERIVATES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2013-11-07 | — | — | US | disclosed |
| EP-2280706-B1 | LIPOPROTEIN LIPASE-ACTIVATING COMPOSITIONS COMPRISING BENZENE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2013-01-02 | — | — | EP | disclosed |
| CN-102026637-B | Lipoprotein lipase-activating compositions comprising benzene derivates | OTSUKA PHARMA CO LTD | 2012-12-12 | — | — | CN | disclosed |
| CN-102026637-A | Lipoprotein lipase-activating compositions comprising benzene derivates | OTSUKA PHARMA CO LTD | 2011-04-20 | — | — | CN | disclosed |
| US-20110065728-A1 | LIPOPROTEIN LIPASE-ACTIVATING COMPOSITIONS COMPRISING BENZENE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2011-03-17 | — | — | US | disclosed |
| US-20110065728-A1 | LIPOPROTEIN LIPASE-ACTIVATING COMPOSITIONS COMPRISING BENZENE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296342-A1 | LIPOPROTEIN LIPASE-ACTIVATING COMPOSITIONS COMPRISING BENZENE DERIVATES | LPL, LIPC, LIPE | PDE4A 690/4885PDE4B 546/4885PDE4C 1031/4885 |
| US-20110065728-A1 | LIPOPROTEIN LIPASE-ACTIVATING COMPOSITIONS COMPRISING BENZENE DERIVATIVES | LPL, LIPC, LIPE | PDE4A 711/4885PDE4B 601/4885PDE4C 1071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.