Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3116095 | 0.85 | CRHR1 (0.33) | HPGDNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL10298265 | 0.79 | POLB (0.37) | LMNAPOLBMAPK1CYP1A2TDP1 | |
| SCHEMBL11904369 | 0.76 | PIK3CA (0.34) | LMNAPOLBHPGDMAPK1CYP1A2 | |
| SCHEMBL953097 | 0.76 | ALDH1A1 (0.42) | MAPK1CYP1A2TDP1ALOX12ALDH1A1 | |
| SCHEMBL11904180 | 0.62 | MAPT (0.32) | POLBNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL31293788 | 0.61 | CHEK1 (0.44) | POLBHPGDESR2TDP1ALDH1A1 | |
| SCHEMBL15880376 | 0.59 | ALDH1A1 (0.34) | LMNANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL1695044 | 0.59 | MAPT (0.42) | LMNAPOLBCYP1A2TDP1RAB9A | |
| SCHEMBL14109593 | 0.58 | PKM (0.55) | LMNACYP1A2NPC1RAB9AALDH1A1 | |
| SCHEMBL9100453 | 0.57 | MAPT (0.41) | LMNAPOLBCYP1A2TDP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2487178-A1 | PYRAZOLOTHIAZOLE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2012-08-15 | — | — | EP | disclosed |