Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.50 |
| ▸ | GAA | P10253 | 11/20 | 0.50 |
| ▸ | HPGD | P15428 | 9/20 | 0.50 |
| ▸ | GLA | P06280 | 7/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | CASP1 | P29466 | 4/20 | 0.50 |
| ▸ | CASP7 | P55210 | 2/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29921932 | 0.91 | KDM4E (0.53) | MAPTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL11903830 | 0.82 | MAPT (0.61) | MAPTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL11904103 | 0.78 | GPR119 (0.55) | MAPTGAASIRT2SIRT1CA12 | |
| SCHEMBL17781640 | 0.77 | MAPT (0.54) | MAPTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL29921889 | 0.77 | CA12 (0.47) | CA12CA1CA9 | |
| SCHEMBL12470984 | 0.76 | CA12 (0.42) | ALDH1A1GAASIRT2SIRT1CA12 | |
| SCHEMBL731390 | 0.76 | KMT2A (0.53) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL12470702 | 0.75 | SIRT2 (0.62) | SIRT2SIRT1CA12CA1CA9 | |
| SCHEMBL12470609 | 0.75 | CA12 (0.41) | ALDH1A1GAASIRT2SIRT1CA12 | |
| SCHEMBL21788610 | 0.74 | SIRT2 (0.61) | SIRT2SIRT1CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012107262-A1 | DIHYDROBENZOPYRAN, THIOCHROMAN, TETRAHYDROQUINOLEINE AND TETRAHYDRONAPHTALENE DERIVATIVES AND THEIR USE IN ANTICANCER THERAPY | UNIVERSITE DE LIEGE (BE) | 2012-08-16 | — | — | WO | disclosed |
| EP-2487171-A1 | Dihydrobenzopyran, thiochroman, tetrahydroquinoleine and tetrahydronaphthalene derivatives and their use in anti-cancer therapy | Université de Liège (BE) | 2012-08-15 | — | — | EP | disclosed |