Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.62 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.62 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 8/20 | 0.39 |
| ▸ | TLR3 | O15455 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21788610 | 0.87 | SIRT2 (0.61) | SIRT2SIRT1CA12CA1CA9 | |
| SCHEMBL17781644 | 0.78 | HPGD (0.45) | SIRT2TRPV1MEN1KMT2A | |
| SCHEMBL31371256 | 0.75 | SIRT2 (1.00) | SIRT2SIRT1TRPV1RORC | |
| SCHEMBL11904033 | 0.75 | MAPT (0.53) | SIRT2SIRT1CA12CA1CA9 | |
| SCHEMBL6958495 | 0.74 | SIRT2 (0.48) | SIRT2SIRT1CA12CA1CA9 | |
| SCHEMBL29921932 | 0.73 | KDM4E (0.53) | SIRT2SIRT1CA12CA1CA9 | |
| SCHEMBL20809519 | 0.72 | PYGL (0.47) | SIRT2SIRT1CA12CA1CA9 | |
| SCHEMBL14484923 | 0.71 | NPC1 (0.66) | MEN1KMT2A | |
| SCHEMBL8342099 | 0.71 | CYP1A2 (0.63) | MEN1KMT2A | |
| SCHEMBL19859973 | 0.70 | CA12 (0.46) | SIRT2SIRT1CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012107262-A1 | DIHYDROBENZOPYRAN, THIOCHROMAN, TETRAHYDROQUINOLEINE AND TETRAHYDRONAPHTALENE DERIVATIVES AND THEIR USE IN ANTICANCER THERAPY | UNIVERSITE DE LIEGE (BE) | 2012-08-16 | — | — | WO | disclosed |