Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.53 |
| ▸ | MAOB | P27338 | 11/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | GRM5 | P41594 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12316609 | 0.76 | GPR119 (0.55) | GPR119MAOBMAOASMN1; SMN2GRM5 | |
| SCHEMBL11904103 | 0.76 | GPR119 (0.55) | GPR119MAOBMAOANPC1RAB9A | |
| SCHEMBL5110080 | 0.75 | GPR119 (0.54) | GPR119MAOBMAOASMN1; SMN2ALDH1A1 | |
| SCHEMBL16976374 | 0.73 | MAOB (0.50) | GPR119MAOBMAOASMN1; SMN2GRM5 | |
| SCHEMBL12316616 | 0.71 | CYP1A2 (0.63) | GPR119MAOBMAOASMN1; SMN2ALDH1A1 | |
| SCHEMBL12217136 | 0.70 | CYP19A1 (0.49) | GPR119MAOBMAOASMN1; SMN2GRM5 | |
| SCHEMBL3171924 | 0.70 | MAOB (0.44) | GPR119MAOBMAOASMN1; SMN2GRM5 | |
| SCHEMBL6838633 | 0.68 | GPR119 (0.48) | GPR119MAOBMAOASMN1; SMN2GRM5 | |
| SCHEMBL1825223 | 0.68 | GPR119 (0.45) | GPR119MAOBMAOASMN1; SMN2ALDH1A1 | |
| SCHEMBL69670 | 0.68 | MAOB (0.50) | MAOBMAOAGRM5NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2487171-A1 | Dihydrobenzopyran, thiochroman, tetrahydroquinoleine and tetrahydronaphthalene derivatives and their use in anti-cancer therapy | Université de Liège (BE) | 2012-08-15 | — | — | EP | disclosed |