Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 18/20 | 0.46 |
| ▸ | AKT1 | P31749 | 18/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2063729 | 0.87 | GPR119 (0.45) | RPS6KB1AKT1GPR119 | |
| SCHEMBL11904365 | 0.86 | RPS6KB1 (0.48) | RPS6KB1AKT1 | |
| SCHEMBL2063685 | 0.85 | RPS6KB1 (0.51) | RPS6KB1AKT1GPR119 | |
| SCHEMBL2063706 | 0.83 | RPS6KB1 (0.53) | RPS6KB1AKT1 | |
| SCHEMBL11904260 | 0.82 | RPS6KB1 (0.60) | RPS6KB1AKT1 | |
| SCHEMBL2063990 | 0.82 | GPR119 (0.49) | RPS6KB1AKT1GPR119 | |
| SCHEMBL14782276 | 0.81 | AKT1 (0.61) | RPS6KB1AKT1 | |
| SCHEMBL2063679 | 0.80 | RPS6KB1 (0.51) | RPS6KB1AKT1GPR119 | |
| SCHEMBL11904778 | 0.80 | RPS6KB1 (0.62) | RPS6KB1AKT1 | |
| SCHEMBL2063972 | 0.80 | RPS6KB1 (0.49) | RPS6KB1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358710-B1 | AKT AND P70 S6 KINASE INHIBITORS | LILLY CO ELI (US) | 2012-08-15 | — | — | EP | disclosed |