Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 12/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 10/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.41 |
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 3/20 | 0.39 |
| ▸ | FLT3 | P36888 | 3/20 | 0.39 |
| ▸ | KIT | P10721 | 3/20 | 0.39 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.39 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3268373 | 0.83 | KDR (0.32) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL1044420 | 0.79 | KDR (0.59) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL5405508 | 0.76 | KDR (0.41) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL13356509 | 0.75 | KDR (0.45) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL1312585 | 0.74 | KDR (0.52) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL1542333 | 0.73 | KDR (0.75) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL12906990 | 0.72 | KDR (0.53) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL21228957 | 0.70 | KDR (0.50) | KDRPRKAA1PRKAA2PDGFRBFGFR1 | |
| SCHEMBL3268634 | 0.70 | ALDH1A1 (0.39) | ALDH1A1IGF1RKMT2A | |
| SCHEMBL1079387 | 0.69 | KDR (0.47) | KDRPRKAA1PRKAA2PDGFRBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313371-B1 | PROCESS FOR PREPARING A 3-PYRROLE SUBSTITUTED 2-INDOLINONE MALATE SALT | MEDICHEM SA (ES) | 2012-08-15 | — | — | EP | claimed |