Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 9/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 5/20 | 0.39 |
| ▸ | FLT3 | P36888 | 4/20 | 0.39 |
| ▸ | CSF1R | P07333 | 3/20 | 0.39 |
| ▸ | KIT | P10721 | 3/20 | 0.39 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.39 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1044420 | 0.80 | KDR (0.59) | KDRPRKAA1PDGFRBPRKAA2FGFR1 | |
| SCHEMBL1312585 | 0.80 | KDR (0.52) | KDRPRKAA1PDGFRBPRKAA2FGFR1 | |
| SCHEMBL13356509 | 0.76 | KDR (0.45) | KDRPRKAA1PDGFRBPRKAA2FGFR1 | |
| SCHEMBL6088559 | 0.76 | KDR (0.46) | KDRPRKAA1PDGFRBPRKAA2FGFR1 | |
| SCHEMBL11904724 | 0.76 | KDR (0.41) | KDRPRKAA1PDGFRBPRKAA2FGFR1 | |
| SCHEMBL6089467 | 0.76 | KDM4E (0.37) | KDRKMT2AKDM4EALDH1A1CHEK1 | |
| SCHEMBL5401668 | 0.75 | L3MBTL1 (0.45) | KDRPDGFRBFGFR1MEN1KMT2A | |
| SCHEMBL6091127 | 0.75 | KDR (0.40) | KDRPRKAA1PDGFRBPRKAA2FGFR1 | |
| SCHEMBL6088913 | 0.74 | KDR (0.39) | KDRPRKAA1PDGFRBPRKAA2FGFR1 | |
| SCHEMBL12906990 | 0.73 | KDR (0.53) | KDRPRKAA1PDGFRBPRKAA2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7157577-B2 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-7157577-B2 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-7157577-B2 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | SUGEN INC. (US) | 2007-01-02 | — | — | US | disclosed |
| US-20040266843-A1 | Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK) | SUGEN, INC. | 2004-12-30 | — | — | US | disclosed |
| US-20040204407-A1 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | SUGEN INC. | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204407-A1 | 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors | DMPK, MAP3K20, PHKG1 | KDR 1657/4885PRKAA1 114/4885PDGFRB 913/4885 |
| US-20040266843-A1 | Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK) | CHEK2, CHEK1, ATM | KDR 1541/4885PRKAA1 348/4885PDGFRB 1414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.