Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5196533 | 0.99 | LMNA (0.57) | LMNAHDAC1HDAC6NPC1GLA | |
| SCHEMBL5492366 | 0.75 | ALOX15 (0.64) | LMNANPC1L3MBTL1POLBHTT | |
| SCHEMBL5407957 | 0.70 | LMNA (0.63) | LMNANPC1L3MBTL1HTTHPGD | |
| SCHEMBL10774226 | 0.70 | FDPS (0.41) | LMNAHDAC1HDAC6FDPSMEN1 | |
| SCHEMBL3691691 | 0.69 | FDPS (0.48) | LMNAHDAC1HDAC6NPC1MAPK1 | |
| SCHEMBL15741497 | 0.68 | LMNA (0.56) | LMNAGLADEGS1POLBHTT | |
| SCHEMBL5041084 | 0.65 | FDPS (0.37) | LMNAHDAC1HDAC6MAPK1FDPS | |
| SCHEMBL11061438 | 0.65 | LMNA (0.50) | LMNADEGS1POLBRAB9AMEN1 | |
| SCHEMBL11172485 | 0.65 | FDPS (0.44) | LMNAHDAC1HDAC6NPC1RAB9A | |
| SCHEMBL10500165 | 0.65 | FDPS (0.44) | LMNAHDAC1HDAC6FDPSMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486039-A1 | PURINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | Sloan Kettering Institute For Cancer Research (US) | 2012-08-15 | — | — | EP | disclosed |