Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 8/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725168 | 0.85 | SUV39H2 (0.46) | CHEK1ACHEIGF1RCDK2IKBKB | |
| SCHEMBL3729496 | 0.81 | GSK3B (0.40) | CHEK1ACHETTKCCNA2CDK2 | |
| SCHEMBL3727024 | 0.81 | GSK3B (0.40) | CHEK1ACHETTKCCNA2CDK2 | |
| SCHEMBL3725345 | 0.81 | USP30 (0.38) | CHEK1ACHEIGF1RTTKCCNA2 | |
| SCHEMBL3727829 | 0.81 | GSK3B (0.40) | CHEK1ACHETTKCCNA2CDK2 | |
| SCHEMBL473715 | 0.81 | GSK3B (0.40) | CHEK1ACHETTKCCNA2CDK2 | |
| SCHEMBL11908966 | 0.81 | CHRM1 (0.45) | CHEK1ACHEMAPTGSK3BDYRK1A | |
| SCHEMBL11909192 | 0.78 | CHEK1 (0.40) | CHEK1ACHEIGF1RTTKCCNA2 | |
| SCHEMBL11908837 | 0.78 | SUV39H2 (0.44) | IKBKBPIM1 | |
| SCHEMBL11908405 | 0.78 | MARK3 (0.40) | CHEK1ACHEIGF1RTTKCCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120208809-A1 | 9H-PYRROLO[2,3-B: 5,4-C'] DIPYRIDINE AZACARBOLINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208809-A1 | 9H-PYRROLO[2,3-B: 5,4-C'] DIPYRIDINE AZACARBOLINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | NPR3, CCNH, CBR3 | CHEK1 1152/4885ACHE 4455/4885IGF1R 1077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.