Icosapent Ethyl

Icosapent Ethyl

SCHEMBL119167

CC/C=C/C/C=C/C/C=C/C/C=C/C/C=C/CCCC(=O)OCC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 2/20 1.00
NR1I2 O75469 2/20 1.00
PTGS2 P35354 2/20 1.00
PGR P06401 1/20 1.00
PDE4D Q08499 1/20 1.00
ALDH1A1 P00352 7/20 0.87
CYP3A4 P08684 2/20 0.87
ALOX15 P16050 2/20 0.87
HSD17B10 Q99714 2/20 0.87
TDP1 Q9NUW8 2/20 0.87
TSHR P16473 1/20 0.87
CYP19A1 P11511 4/20 0.62
F7 P08709 3/20 0.62
F3 P13726 3/20 0.62
PPARG P37231 3/20 0.62
OXER1 Q8TDS5 3/20 0.62
PTGS1 P23219 2/20 0.62
KMT2A Q03164 2/20 0.62
PPARD Q03181 2/20 0.62
PPARA Q07869 2/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Icosapent Ethyl SCHEMBL28366934 1.00 ADORA3 (1.00) ADORA3NR1I2PTGS2PGRPDE4D
Icosapent Ethyl SCHEMBL28253974 1.00 ADORA3 (1.00) ADORA3NR1I2PTGS2PGRPDE4D
Icosapent Ethyl SCHEMBL123305 1.00 ADORA3 (1.00) ADORA3NR1I2PTGS2PGRPDE4D
Icosapent Ethyl SCHEMBL119168 1.00 ADORA3 (1.00) ADORA3NR1I2PTGS2PGRPDE4D
Icosapent Ethyl SCHEMBL29356075 0.97 ADORA3 (0.93) ADORA3NR1I2PTGS2PGRPDE4D
SCHEMBL28628574 0.95 ALDH1A1 (0.97) ADORA3NR1I2PTGS2PGRPDE4D
SCHEMBL21670446 0.95 ALDH1A1 (0.97) ADORA3NR1I2PTGS2PGRPDE4D
SCHEMBL21670445 0.95 ALDH1A1 (0.97) ADORA3NR1I2PTGS2PGRPDE4D
SCHEMBL18924751 0.94 ADORA3 (0.89) ADORA3NR1I2PTGS2PGRPDE4D
SCHEMBL4814473 0.93 ALDH1A1 (1.00) ADORA3NR1I2PTGS2PGRPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 442 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250090547-A1 EPA-EE LIPID NANOCOMPOSITE, FORMULATION THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) 2025-03-20 US disclosed
EP-4458352-A1 EICOSAPENTAENOIC ACID ESTER DERIVATIVES FOR THE TREATMENT OF OBESITY Technische Universität Dresden (DE) 2024-11-06 EP disclosed
WO-2023126026-A9 EPA-EE LIPID NANOCOMPOSITE, FORMULATION THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF 中国科学院上海药物研究所 2024-09-12 WO disclosed
CN-118524840-A EPA-EE nano lipid composition, preparation method and application thereof 中国科学院上海药物研究所 2024-08-20 CN disclosed
US-20240216322-A1 COMPOSITIONS AND METHODS FOR TREATING AND/OR PREVENTING CARDIOVASCULAR DISEASE AMARIN PHARMACEUTICALS IRELAND LIMITED (IE) 2024-07-04 US disclosed
CN-118067865-A Quantitative detection method for middle ear cholesteatoma tissue differential markers 浙江大学 2024-05-24 CN disclosed
CN-118032972-A Screening method of middle ear cholesteatoma bone-breaking progress related metabolites 浙江大学 2024-05-14 CN disclosed
US-20240148683-A1 STABLE PHARMACEUTICAL COMPOSITION AND METHODS OF USING SAME AMARIN PHARMACEUTICALS IRELAND LIMITED (IE) 2024-05-09 US disclosed
US-20240024277-A1 METHODS OF TREATING HYPERTRIGLYCERIDEMIA AMARIN PHARMA, INC. 2024-01-25 US disclosed
US-20240016803-A1 PHARMACEUTICAL COMPOSITION COMPRISING EICOSAPENTAENOIC ACID AND DERIVATIVES THEREOF AND A STATIN AMARIN PHARMACEUTICALS IRELAND LIMITED (IE) 2024-01-18 US disclosed
WO-2007030697-A2 MODULATION OF NEUROGENESIS BY HDAC INHIBITION BRAINCELLS, INC. (US) 2007-03-15 WO disclosed
WO-2007025177-A2 NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION BRAINCELLS, INC. (US) 2007-03-01 WO disclosed
US-20070049576-A1 NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION BRAINCELLS, INC. (US) 2007-03-01 US disclosed
US-20060121583-A1 New method for synthesizing ceramide-type compounds LASSALLE LAURENT 2006-06-08 US disclosed
EP-0782827-B1 USE OF A BALANCING AGENT FOR OMEGA-6 AND OMEGA-3 UNSATURATED FATTY ACIDS SUNTORY LTD (JP) 2003-10-01 EP disclosed
US-20020095007-A1 Lewis acid-catalyzed polymerization of biological oils and resulting polymeric materials IOWA STATE UNIVERSITY RESEARCH FOUNDATION 2002-07-18 US disclosed
US-6159507-A Food composition containing an omega-6/omega-3 unsaturated fatty acid balance modifier SUNTORY LIMITED (JP) 2000-12-12 US disclosed
US-5948451-A Method of modifying the balance of omega unsaturated fatty acids using a dioxabicyclo octane derivative SUNTORY LIMITED (JP) 1999-09-07 US disclosed
EP-0782827-A1 FOOD COMPOSITION CONTAINING BALANCING AGENT FOR $g(v)-6 AND $g(v)-3 UNSATURATED FATTY ACIDS SUNTORY LIMITED (JP) 1997-07-09 EP disclosed
US-5034414-A Nutrients in emulsions for transfusions containing unsaturated acids and esters TERUMO KABUSHIKI KAISHA (JP) 1991-07-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070049576-A1 NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION CHRNB2, CHAT, CHRNB4 ADORA3 293/4885NR1I2 1746/4885PTGS2 1237/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.