Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14282584 | 0.86 | AKR1C3 (0.44) | AKR1C3SRD5A2TDP1LMNATP53 | |
| SCHEMBL8986306 | 0.81 | AKR1C3 (0.40) | AKR1C3SRD5A2TDP1LMNATP53 | |
| SCHEMBL13328292 | 0.79 | ALDH1A1 (0.47) | AKR1C3SRD5A2TDP1LMNACES2 | |
| SCHEMBL13638717 | 0.79 | AKR1C3 (0.38) | AKR1C3SRD5A2TDP1LMNATP53 | |
| SCHEMBL8986301 | 0.79 | AKR1C3 (0.38) | AKR1C3SRD5A2TDP1LMNATP53 | |
| SCHEMBL11922326 | 0.79 | AKR1C3 (0.38) | AKR1C3SRD5A2TDP1LMNATP53 | |
| SCHEMBL8986300 | 0.78 | AKR1C3 (0.38) | AKR1C3SRD5A2TDP1LMNATP53 | |
| SCHEMBL8986302 | 0.75 | MEN1 (0.36) | AKR1C3SRD5A2LMNATP53CES2 | |
| SCHEMBL8986303 | 0.74 | LMNA (0.37) | AKR1C3SRD5A2TDP1LMNATP53 | |
| SCHEMBL16270676 | 0.70 | TDP1 (0.32) | TDP1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120209009-A1 | SYNTHETIC ROUTE TO ABCD-PORPHYRINS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120209009-A1 | SYNTHETIC ROUTE TO ABCD-PORPHYRINS | ABCB7, ALAD, SLC39A14 | AKR1C3 1386/4885SRD5A2 1077/4885TDP1 2820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.